妊娠期孕妇人乳头状瘤病毒感染的分型与母婴垂直传播的相关性研究  

Correlation between genotyping of human papillomavirus infections in gestational women and mother-to-infant vertical transmission

作　　者：魏振玲[1] 黄华[2] 

机构地区：[1]郑州大学第一附属医院超声科,河南郑州450052 [2]郑州大学第一附属医院妇产科,河南郑州450052

出　　处：《中华医院感染学杂志》2014年第1期12-14,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅青年创新基金(2011-WQN001)

摘　　要：目的探讨妊娠期孕妇人乳头状瘤病毒(HPV)感染的分型与母婴垂直传播的相关性,分析妊娠期HPV感染对分娩新生儿的影响。方法回顾性分析医院产前检查且分娩的HPV感染产妇262例(HPV感染组)及按照2∶1比例选取的131例无HPV感染产妇(对照组)资料,分析HPV感染分型、母婴垂直感染情况。结果 262例HPV感染孕妇16种高危型及5种低危型均有检出,其中单型感染者210例,占80.15%,多型感染者52例,占19.85%,高危型感染者238例,占90.84%,低危型感染者24例,占9.16%;HPV感染组产妇阴道分娩、剖宫产、胎儿宫内生长受限、早产、胎膜早破、呼吸窘迫综合征及产妇产后出血发生率分别为67.94%、32.06%、3.05%、6.49%、11.83%、3.44%、1.15%,对照组分别为71.76%、28.24%、2.29%、4.58%、10.69%、3.81%、0.76%,两组比较差异均无统计学意义;分娩新生儿HPV感染率46.18%,均为隐形感染,其中咽拭子、外阴分泌物、咽拭子及外阴分泌物同时感染率分别为19.85%、22.52、3.82%,53例新生儿HPV感染型别与孕妇感染型别一致,68例感染型别与孕妇不一致。结论妊娠期孕妇HPV感染主要以单一型感染、高危型感染为主,孕妇HPV感染可通过垂直传播途径引起宫内感染,造成新生儿HPV隐形感染,但与分娩方式及妊娠结局无关,新生儿HPV感染型别与孕妇并不完全一致,原因尚不完全明确。OBJECTIVE To explore the correlation between the genotyping of human papilloma virus（HPV）infections in the gestational women and the mother-to-infant vertical transmission and observe the influence of the gestational HPV infections on the newborns.METHODS Totally 262pregnant women who took prenatal examination and gave birth with HPV infections and 131pregnant women without HPV infection who were chosen in a 2∶1 ratio were enrolled in the study,then the clinical data of the enrolled subjects were retrospectively analyzed,the genotyping of HPV infections and the mother-to-infant vertical transmission were analyzed.RESULTS Both the 16 high-risk types and 5low-risk types have been detected in the 262pregnant women with HPV infections,including 210（80.15%）cases of monotype infection and 52（49.85%）cases of multiple type infections;there were 238（90.84%）cases of high-risk HPV infections and 24（9.16%）cases of low-risk HPV infection.The incidence of vaginal delivery was 67.94% in the HPV infection group,71.76% in the control group;the incidence of cesarean section was 32.06% in the HPV infection group,28.24% in the control group;the incidence of fetal intrauterine growth restriction was 3.05% in the HPV infection group,2.29% in the control group;the incidence of premature delivery was 6.49% in the HPV infection group,4.58% in the control group;the incidence of premature rapture of membrane was 11.83% in the HPV infection group,10.69% in the control group;the incidence of respiratory distress syndrome was 3.44% in the HPV infection group,3.81% in the control group;the incidence of postnatal hemorrhage was 1.15% in the HPV infection group,0.76% in the control group,the differences between the two groups were not significant.The incidence of HPV infection was 46.18% in the newborns,all of whom were with invisible infection;the infection rates of the subjects with the specimens obtained from the throat swab,genital secretions,and throat swab with genital secretions were 19.85%,22.52,and 3.82%,respective

关 键 词：人乳头状瘤病毒 妊娠 垂直传播 

分 类 号：R373[医药卫生—病原生物学]