慢性阻塞性肺疾病患者肺部感染血清炎性因子变化研究  

Study on changes of serum inflammatory factors of chronic obstructive pulmonary disease patients complicated with pulmonary infections

作　　者：李宏[1] 阳甜[1] 杨岚[1] 

机构地区：[1]西安交通大学医学院第一附属医院呼吸与危重症医学科,陕西西安710061

出　　处：《中华医院感染学杂志》2014年第1期17-18,27,共3页Chinese Journal of Nosocomiology

基　　金：陕西省科技计划基金项目(2011K12-15)

摘　　要：目的探讨慢性阻塞性肺疾病患者肺部感染患者血清炎性因子的变化情况,为其诊治提供依据。方法选取2012年1月-2013年1月医院的34例慢性阻塞性肺疾病发生肺部感染患者为A组,另将同一时期的34例慢性阻塞性肺疾病患者选为B组,同一时期的于医院进行体检的34名健康人员选为C组,将3组人员的血清促炎因子与抑炎因子水平进行检测比较。结果 A组的血清IL-2水平为(4.24±0.56)μg/L,低于B组的(6.57±0.79)μg/L与C组的(8.89±1.13)μg/L,血清IL-6、TNF-α与IFN-γ水平分别为(16.33±1.78)pg/ml、(2.31±0.24)ng/ml和(20.32±2.14)μg/ml,其均高于B组的(11.74±1.29)pg/ml、(1.57±0.15)ng/ml和(14.68±1.62)μg/ml与C组的(6.86±0.92)pg/ml、(0.92±0.10)ng/ml和(8.78±0.99)μg/ml,而A组患者中重度肺部感染患者血清IL-2水平低于轻度感染患者,IL-6、TNF-α与IFN-γ水平则高于轻度感染患者,差异均有统计学意义(P<0.05)。结论慢性阻塞性肺疾病患者肺部感染患者血清炎性因子波动相对较大,对于感染的存在及严重程度均有一定的指示作用。OBJECTIVE To explore the changes of serum inflammatory factors of the chronic obstructive pulmonary disease（COPD）patients complicated with pulmonary infections so as to guide the clinical diagnosis and treatment. METHODS Totally 34cases of COPD patients complicated with pulmonary infections,who were treated in the hospital from Jan 2012to Jan 2013,were assigned as the group A,meanwhile 34cases of COPD patients were chosen as the group B,and 34healthy people who underwent physical examination during the same period were set as the group C,then the levels of the serum proinflammatory factors or the suppressed inflammatory factors were detected and compared among the three groups.RESULTS The serum IL-2level of the group A was（4.24±0.56） μg/L,lower than（6.57±0.79）μg/L of the group B and（8.89±1.13）μg/L of the group C;the serum IL-6level of the group A was（16.33±1.78）pg/ml,higher than（11.74±1.29）pg/ml of the group B and（6.86±0.92） pg/ml of the group C;the serum TNF-αlevel of the group A was（2.31±0.24）ng/ml,higher than（1.57±0.15）ng/ml of the group B and（0.92±0.10）ng/ml of the group C;the serum IFN-γlevel of the group A was（20.32±2.14）μg/ml,higher than（14.68±1.62）ug/ml of the group B and（8.78±0.99）μg/ml of the group C,however,the serum IL-2level of the patients with moderate and severe pulmonary infections was lower than that of the patients with mild infections,while the levels of serum IL-6,TNF-α,and IFN-γof the patients with moderate and severe pulmonary infections were higher than those of the patients with mild infections,the differences were significant（P0.05）.CONCLUSIONThe serum inflammatory factors of the COPD patients complicated with pulmonary infections fluctuate to a larger extent,which may indicate the presence of infections and the severity of disease.

关 键 词：慢性阻塞性肺疾病 肺部感染 炎性因子 变化 

分 类 号：R563.1[医药卫生—呼吸系统]