高敏C-反应蛋白与降钙素原对感染性疾病预后评估研究  

Clinical values of high-sensitivity C-reactive protein and procalcitonin in evaluation of condition of infectious diseases and prognosis

作　　者：杨欣悦[1] 钱传云[1] 樊楚明[1] 

机构地区：[1]云南省第一人民医院ICU,云南昆明650032

出　　处：《中华医院感染学杂志》2014年第1期22-24,共3页Chinese Journal of Nosocomiology

基　　金：云南省自然科学基金资助项目(2004C0045M)

摘　　要：目的探讨高敏C-反应蛋白(hs-CRP)、降钙素原(PCT)在感染性疾病病情及预后评估的临床应用价值。方法 121例感染性疾病设为感染组,88例非感染性疾病设为非感染组,68名健康体检人群为对照组,比较各组hs-CRP、PCT,研究感染性疾病中不同临床转归患者hs-CRP、PCT动态变化。结果感染组、非感染组及正常对照组PCT、hs-CRP血清水平及白细胞(WBC)计数差异均有统计学意义(P<0.05),非感染组、感染组PCT、hsCRP血清水平及WBC计数较正常对照组均出现升高,感染组升高更为显著;感染组中预后不良组入院急性生理学与慢性健康状况评分(APACHEⅡ评分)、PCT、hs-CRP血清水平及WBC计数均高于预后良好组;感染组患者PCT(r=0.624,P<0.05)、hs-CRP(r=0.547,P<0.05)与APACHEⅡ呈正相关,WBC与APACHEⅡ无相关性;预后良好组PCT、hs-CRP血清浓度均低于相同时间段预后不良组血清水平且呈现逐渐降低走势,预后不良组则维持较高浓度水平。结论降钙素原与C-反应蛋白在感染性疾病对病情及预后的评估有重要的临床应用价值。OBJECTIVE To explore the clinical values of high-sensitivity C-reactive protein（hs-CRP）and procalcitonin（PCT）in evaluation of severity of infectious diseases and prognosis.METHODS Totally 121cases of infectious diseases were chosen as the infection group,while 88cases of non-infectious diseases were set as the non-infection group,and 68healthy people were set as the control group,then the levels of the hs-CRP and PCT were compared,and the dynamic change of the hs-CRP or PCT of the patients with different clinical outcomes was observed.RESULTS The difference in the level of serum PCT,hs-CRP,or while blood cell（WBC）counts between the infection group,the non-infection group,and the control group was significant（P0.05）;the levels of the serum PCT and hs-CRP as well as the WBC counts of the non-infection group and the infection group were significantly elevated as compared with the control group,which were elevated most significantly in the infection group. In the infection group,the APACHEⅡscore,levels of serum PCT and hs-CRP,and WBC counts of the subjects with poor prognosis were higher than those of the subjects with good prognosis,indicating the PCT（r=0.624,P 0.05）and hs-CRP（r=0.547,P0.05）were positively correlated with the APACHEⅡ score and that the WBC count was negatively correlated with the APACHEⅡ score;the concentrations of the serum PCT and hsCRP of the subjects with good prognosis were lower than those of the subjects with poor prognosis at the same time point and showed a downward trend;while the subjects with poor prognosis maintained the concentrations at a high level.CONCLUSIONThe PCT and CRP have great clinical value in evaluation of conditions of the infectious diseases and the prognosis.

关 键 词：高敏C-反应蛋白 降钙素原 感染性疾病 急性生理学与慢性健康状况评分 

分 类 号：R446.62[医药卫生—诊断学]