NICU鲍氏不动杆菌的耐药性监测  

Antimicrobial resistance monitoring of Acinetobacter baumannii in intensive care unit of neurosurgery

作　　者：孙迎娟[1] 何宏[2] 孙晓玲[1] 黄伟丽[1] 

机构地区：[1]青岛大学医学院附属医院感染管理科,山东青岛266003 [2]青岛大学医学院附属医院检验科,山东青岛266003

出　　处：《中华医院感染学杂志》2014年第1期45-46,49,共3页Chinese Journal of Nosocomiology

基　　金：青岛市科技计划公共领域支撑基金项目(11-2-1-1-nsh)

摘　　要：目的探讨医院神经外科重症监护病房(NICU)患者中鲍氏不动杆菌(ABA)的感染情况及耐药趋势,为ABA感染的预防与控制提供科学依据。方法对2011年7月1日-2012年6月30日NICU感染患者各种标本分离的鲍氏不动杆菌药敏检测结果进行回顾性分析,ABA分离与鉴定严格按照《全国临床检验操作规程》进行,采用自动微生物分析仪ATB Expression及配套试剂进行细菌鉴定和药敏试验。结果共分离出ABA134株,占总分离病原菌的8.8%;感染源于以呼吸道为主,占79.8%;ABA对临床常用抗菌药物耐药严重,对碳青霉烯类抗菌药物的耐药率均>60.00%,仅对头孢哌酮/舒巴坦、阿米卡星保持较高抗菌活性,耐药率分别为7.46%、4.48%。结论 NICU患者感染鲍氏不动杆菌耐药严重,合理使用抗菌药物、加强ABA耐药性监测及控制十分重要。OBJECTIVE To approach explore the antimicrobial infection and drug resistance of Acinetobacter baumannii（ABA）in intensive care unit of neurosuegery（NICU）,and to provide the scientific evidence for prevention and control of ABA infection.METHODS A retrospective analysis was conducted on the antibiotic susceptibility test results of clinical isolates of ABA from infected patients in NICU from Jul.1 2011to Jun.30 2012,were analyzed retrospectively.Referring to National Clinical Laboratory Procedures,ABA were isolated and identified.And The bacteria identification and antibiotic susceptibility were performed by ATB expression and auxiliary kits were used.RESULTS A total of 134strains of ABA pathogens were isolated,among them 134strains were ABA（accounting for 8.8%）,and 79.8% of them came from respiratory tract.Results of susceptibility test showed that ABA had been high resistant to clinical commonly used antibiotics in different degrees.Some isolates of ABA were multi-resistant to some antibiotics.The resistance rates of carbapenems were above 60%.Only cefoperazone-sulbactam and amikacin were the most active antibiotics,and the drug resistance rates were 7.46% and 4.48%,respectively.CONCLUSIONThe drug resistance rates of ABA in NICU patients are severe.present multidrug resistance.It is important to control and carry out surveillance of bacterial drug resistance and appropriately using the antibiotics.

关 键 词：神经外科重症监护病房 鲍氏不动杆菌 感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]