盐酸氨溴索治疗高血压脑出血患者术后肺部感染的临床研究  被引量:26

Clinical significance of ambroxol hydrochloride in treatment of postoperative pulmonary infections in hypertensive intracerebral hemorrhage patients

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作  者:徐海松[1] 胡燕侠 姜启周[3] 

机构地区:[1]杭州师范大学附属医院神经外科,浙江杭州310015 [2]杭州市江干区闸弄口街道社区卫生服务中心,浙江杭州310015 [3]杭州市第二人民医院神经外科,浙江杭州310015

出  处:《中华医院感染学杂志》2014年第1期185-187,共3页Chinese Journal of Nosocomiology

基  金:浙江省卫生厅基金项目(ZW-2010B1018)

摘  要:目的探讨盐酸氨溴索用于高血压脑出血患者手术后肺部感染治疗的临床意义,提高临床对高血压脑出血术后肺部感染的防治水平。方法选取高血压脑出血术后发生肺部感染的患者300例,随机分为两组各150例,对照组实施常规治疗,观察组在对照组基础上给予盐酸氨溴索静脉注射,对两组患者治疗效果进行评价,且对患者的临床症状、体征和肺部X线表现进行评分,采用SPSS13.0软件进行统计分析。结果观察组临床显效率和总有效率分别为66.67%和93.33%,对照组分别为42.67%和83.33%,两组比较差异有统计学意义(P<0.05);两组患者经过治疗症状、体征以及X线检查评分均较治疗前有所降低,治疗后对照组症状、体征以及X线检查评分分别为(4.68±1.86)、(1.09±0.02)、(1.39±0.17)分,观察组分别为(2.06±1.22)、(0.58±0.05)、(0.72±0.15)分,观察组患者降低更为明显,两组比较差异有统计学意义(P<0.05);两组患者均无明显不良反应发生,差异无统计学意义。结论盐酸氨溴索是一种安全、高效治疗高血压脑出血术后肺部感染的药物,可以改善患者的临床预后,有着积极的临床应用价值。OBJECTIVE To explore the clinical significance of ambroxol hydrochloride in treatment of postoperative pulmonary infections in the patients with hypertensive intracerebral hemorrhage so as to improve the level of pre- vention and treatment of postoperative pulmonary infections in the hypertensive intracerebral hemorrhage patients. METHODS Totally 300 cases of hypertensive intracerebral hemorrhage patients with postoperative pulmonary in- fections were enrolled in the study and randomly divided into two groups with 150 cases in each, then the observa- tion group was given the additional intravenous administration of ambroxol hydroehloride on the basis of the con- trol group, the therapeutic effect was evaluated, the clinical symptoms, body signs, and chest X-ray findings were observed and scored, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS The clinical effective rate was 66.67% in the observation group, 42.67% in the control group the total effective rate was 93.33 ~ in the observation group, 83.33 % in the control group, the differences between the two groups were significant(P〈0.05). Through the treatment, the scores of the clinical symptoms, body signs, and chest X-ray examination of both groups were declined as compared with those before the treatments the score of the clinical symptoms after the treatment was (4.68 ±1.86) points in the control group, (2.06 ±1.22) points in the obser- vation groups the score of the body signs was (1.09±0.02) points in the control group, (0.58 ±0.05) points in the observation groups the score of the chest X-ray examination was (1.39 ±0.17) points in the control group, (0. 72± 0. 15) points in the observation group, the differences between the two groups were significant (P〈0.05) the adverse reactions occurred in neither the two groups, the difference was not significant. CONCLUSION As a safe and high-efficiency drug for the treatment of postoperative pulmonary infections in the hypertensive in-

关 键 词:盐酸氨溴索 高血压 脑出血 肺部感染 

分 类 号:R563.1[医药卫生—呼吸系统]

 

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