碱性橙Ⅱ-D_5的合成研究  

Syntheses of Labeled Basic OrangeⅡ-D_5

作　　者：徐仲杰[1] 卢伟京[1] 孙雯[1] 卢浩[1] 颜章伟[1] 江浙 

机构地区：[1]上海化工研究院技术开发中心,上海200062

出　　处：《化学试剂》2014年第1期83-85,共3页Chemical Reagents

基　　金：上海市青年科技启明星计划资助项目(12QB-1402200);2012年科技部转制院所专项资助项目(2012EG-116257)

摘　　要：以苯胺-D5为前体,经重氮化后和间苯二胺偶合,然后高温转位得到标题化合物。按消耗的苯胺-D5计算,其收率为75.8%。产品结构经质谱和核磁共振波谱等表征确定,纯度99.2%,氘同位素丰度99.1 atom%D,可作为食品安全领域检测用内标试剂。This work presents the efficient synthesis of Basic Orange Ⅱ-D5 with aniline-D5 as the common substrate,whieh is mainly obtained via cliazotization and a coupling reaction with m-phenylenediamine, followed by the translocation at high temperature. The yields of Basic Orange Ⅱ-D5 was 75.8% based on aniline-D5 consumed. The structure was confirmed by NMR and LC-MS. The chemical purity is 99. 2% and deuterium isotopic enrichment is 99.1 atom% D. The compound could be used as internal standards in the field of food safety testing.

关 键 词：同位素标记 碱性橙Ⅱ-D5 表征 

分 类 号：TQ463[化学工程—制药化工]