血清可溶性上皮钙黏蛋白与胃癌中医证型关系研究  

Correlation Between TCM Syndromes of Patients with Gastric Carcinoma and Level of Serum sE-cad

作　　者：李响[1] 张军峰[2] 詹瑧[2] 杨亚平[1] 

机构地区：[1]南京中医药大学中医诊断教研室,江苏南京210023 [2]南京中医药大学中西医结合学科,江苏南京210023

出　　处：《中国中医药信息杂志》2014年第1期30-32,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30973715;81001502);江苏省自然科学基金(BK2008461);高等学校博士学科点专项科研基金(20103237110011);江苏高校优势学科建设工程基金(2010年);江苏省高校自然科学基金(10KJB360004)

摘　　要：目的探讨胃癌患者辨证分型与血清可溶性上皮钙黏蛋白(sE-cad)水平之间的关系。方法对190例胃癌患者进行辨证分型,采用酶联免疫吸附法检测患者血清sE-cad水平,SPSS16.0软件分析胃癌证型与血清sE-cad水平的相关性。结果瘀血内阻证sE-cad与脾胃虚弱、胃热阴伤、气阴两虚证之间差异有统计学意义(P<0.05)。性别分层分析显示,男性瘀血内阻证与脾胃虚弱、胃热阴伤、气阴两虚证之间差异有统计学意义(P<0.05),女性脾胃虚弱证与气阴两虚证之间差异有统计学意义(P<0.05)。结论血清sE-cad水平与胃癌患者辨证分型存在相关性。Objective To explore the correlation between the syndromes of patients with gastric carcinoma and level of serum sE-cad. Methods Totally 190 cases of different syndromes of patients with gastric carcinoma were collected, and serum level of sE-cad was measured by ELISA. The correlation between the syndromes of gastric cancer and level of serum sE-cad was analyzed by SPSS 16.0 software. Results The level of serum sE-cad of interior retention of blood stasis syndrome was significant different with that of deficiency syndrome of spleen and stomach, yin impairment syndrome due to stomach heat, deficiency syndrome of both qi and yin （P〈0.05）. Besides, this result was the same as the results of gender stratification analysis in men. The difference in serum level of sE-cad in the type of deficiency syndrome of spleen and stomach was significant different with that of deficiency syndrome of both qi and yin in women （P〈0.05）. Conclusion Level of serum sE-cad was correlated with syndrome type of patients with gastric carcinoma.

关 键 词：胃癌 证型 血清可溶性上皮钙黏蛋白 相关性 

分 类 号：R273.52[医药卫生—中西医结合]