五子补肾胶囊成型工艺研究  

Research on Formulation Process of Wuzibushen Capsules

作　　者：梁学政[1] 唐勇琛[1] 吴昭璇[1] 甄汉深[2] 丘琴[2] 黄晓玉[2] 

机构地区：[1]柳州市中医院,广西柳州545001 [2]广西中医药大学,广西南宁530001

出　　处：《中国中医药信息杂志》2014年第1期71-73,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广西壮族自治区卫生厅中医药医院制剂类课题(GZYZ-10-36)

摘　　要：目的探讨五子补肾胶囊的成型工艺。方法以吸湿率为指标考察辅料的种类和配比,并考察颗粒的休止角、堆密度和临界相对湿度。结果确定淀粉为本处方的辅料,纯浸膏与淀粉的比例为1.15∶1.25,80%乙醇湿法制粒,60℃下干燥,制得颗粒流动性好,临界相对湿度应为62%。结论该成型工艺合理、可行,为大生产提供了依据。Objective To optimize the forming process of Wuzibushen Capsules. Methods Category and ratio of accessories were investigated by taking moisture absorption percentage as index. The inspected angle of repose, bulk density and critical relative humidity were also investigated. Results Starch was used as the excipien. Remedium cardinale and starch in the ratio of 1.15 ： 1.25 was more appropriate, 60% alcohol was added, dried at 60 ℃. Granules had a good fluidity, critical relative humidity was about 62%. Conclusion The forming technology was reasonable and provide reliable basis for production.

关 键 词：五子补肾胶囊 成型工艺 微粉学 临界相对湿度 

分 类 号：R283.5[医药卫生—中药学]