负压封闭引流对创面愈合和血浆纤维连接蛋白水平的影响  

Effects of vacuum sealing drainage on wound healing and plasma fibronectin

作　　者：李晨[1] 喻爱喜[1] 白育庭[2] 漆白文[1] 胡祥[1] 

机构地区：[1]武汉大学中南医院显微骨科,430071 [2]湖北科技学院

出　　处：《中华实验外科杂志》2014年第1期190-191,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（81171713）

摘　　要：目的 观察负压封闭引流技术（VSD）治疗创面前后血浆纤维连接蛋白（Fn）水平的变化,探讨VSD的作用机制.方法 20例软组织缺损患者,在使用VSD治疗前、后采集患者血浆样品,检测Fn水平,观察评价创面肉芽组织生长,并测量创面面积,观察创面愈合,分析其与血浆Fn水平的相关性.结果 患者在使用VSD治疗后,血浆Fn水平[（277.69 ±28.34） mg/L]较治疗前[（244.52 ±27.02） mg/L]升高（P＜0.05）；创面肉芽组织评分[（4.73±1.24）分]较治疗前[（2.35±0.89）分]增加（P＜0.05）,并与血浆Fn水平呈正相关（r=0.883,P＜0.05）；创面面积[（165.58±37.35） cm2]较治疗前[（206.30 ±43.40） cm2]缩小（P＜0.05）,并与血浆Fn水平呈负相关（r=-0.661,P＜0.05）.结论 VSD能增加血浆Fn的含量,加快创面肉芽组织的生长,促进创面愈合.Objective To observe the changes in the levels of plasma fibronectin （Fn） before and after vacuum sealing drainage （VSD） in the treatment of wounds,and study the action mechanism of VSD.Methods The plasma samples were collected from 20 patients with soft tissue defect for determination of plasma Fn levels before and after the treatment with VSD.The growth of granulation tissue,the wound area and the wound healing were observed,and their correlation with plasma Fn level was analyzed.Results Before and after the treatment with VSD,the plasma Fn levels were （244.52 ± 27.02） and （277.69 ±28.34） mg/L （P 〈0.05）,and wound granulation tissue score was （2.35 ± 0.89） and （4.73 ± 1.24）（P 〈 0.05）,respectively.The wound granulation tissue score was positively correlated with the plasma Fn level （r =0.883,P 〈 0.05）.The wound area after treatment [（165.58 ± 37.35） cm2] was significantly reduced as compared with that before treatment [（206.30 ± 43.40） em2,P 〈 0.05],and negatively correlated with the plasma Fn level （r =-0.661,P 〈 0.05）.Conclusion VSD can increase the plasma Fn level,speed up wound granulation tissue growth,and promote wound healing.

关 键 词：负压封闭引流 纤维连接蛋白 创面愈合 

分 类 号：R641[医药卫生—外科学]