肾康注射液对高血压肾病大鼠肾脏的保护作用  

Protective effect of Shenkang Injections on kidney function of hypertensive renal damage rats

作　　者：张宇[1] 宋佳[1] 黄琳红[2] 周楠[1] 吕延英 王光建 王俊平 贺建宇[1] 

机构地区：[1]西安交通大学医学院,西安710061 [2]西安交通大学医学院附属红会医院,西安710054 [3]西安世纪盛康药业有限公司,西安710300

出　　处：《西北药学杂志》2014年第1期41-45,共5页Northwest Pharmaceutical Journal

基　　金：陕西省自然科学基金(No.2011JM4018)

摘　　要：目的探讨肾康注射液对高血压肾病大鼠肾脏的影响。方法将32只高血压肾病模型大鼠随机分为4组:模型对照组、阳性对照组、肾康注射液大剂量组、肾康注射液小剂量组;WKY大鼠作为阴性对照组。阳性对照组腹腔注射给予福辛普利钠1.6mg·kg-1,肾康注射液大、小剂量组腹腔分别注射给予肾康注射液,相当于生药剂量为4,2g·kg-1,阴性对照组和模型组腹腔分别注射等体积生理盐水,1d1次,连续给药30d。观察肾康注射液对高血压肾病大鼠的尿24h蛋白、尿β2-微球蛋白、肾脏炎症因子以及肾功能、肾脏病变等的影响。结果与模型组比较,肾康注射液能降低大鼠24h尿蛋白的含量及质量浓度,降低肾脏炎症因子白介素-1β(IL-1β),降低尿素氮、血肌酐、尿酸浓度,改善大鼠肾功能,组间比较差异有统计学意义(P<0.05)。结论肾康注射液能改善高血压大鼠肾功能。Obj ective To explore the influence of Shenkang Inj ections to the kidney of hypertension nephropathy rats.Methods Thirty-two male hypertension nephropathy rats were randomly divided into 4 groups：model group,positive control group and Shenkang Inj ections low and high dose groups.WKY rats were used as the negative control group.The positive control group was given intraperitoneal inj ection of fosinopril sodium at a dose of 1 .6 mg·kg-1 .Shenkang Inj ections groups were respectively given intraperitoneal inj ection of Shenkang Inj ections,administration dose 4 and 2 g · kg-1 ,amount to crude drugs.Negative control group and model group were injected with a same volume of saline intraperitoneal,1 time a day,continuous administration 30 d. The effects of Shenkang Injections on urinary 24 h protein,urinaryβ2-MG,renal inflammatory cytokines,renal function,renal le-sions and so on were observed.Results Compared with the model group,Shenkang Injections can reduce rat 24 h urine protein and kidney inflammation factors,and improve rat kidney function （P〈0.05）.Conclusion Shenkang Injections can improve rat kidney function.

关 键 词：肾康注射液 高血压肾损害 肾功能 炎症因子 

分 类 号：R285.5[医药卫生—中药学]