小柴胡汤加减联合小剂量激素治疗难治性肾病综合征近期疗效及生化指标分析  

Short term efficacy observation of modified Xiaochaihu Decoction combined with small dose of hormone for treating refractory nephrotic syndrome and biochemical indexes analysis

作　　者：周盛杰[1] 王海涛[2] 

机构地区：[1]广东省第二中医院检验科,广州510095 [2]广东省第二中医院肾内科,广州510095

出　　处：《检验医学与临床》2014年第1期18-20,共3页Laboratory Medicine and Clinic

基　　金：广东省建设中医药强省科研立项课题(20122174)

摘　　要：目的研究小柴胡汤加减联合小剂量激素多靶点治疗难治性肾病综合征近期疗效及生化指标。方法选择难治性肾病综合征患者,随机分为给予小柴胡汤加减联合小剂量激素多靶点治疗的观察组和小剂量激素多靶点治疗的对照组,观察两组患者的治疗效果,检测血肌酐、血尿素氮、血红蛋白、内生肌酐清除率、24h尿蛋白等肾功能相关指标和清蛋白、球蛋白、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)等肝功能指标。结果观察组患者治疗总有效率88.33%,疗效明显好于对照组;其血肌酐[(272.83±23.52)μmol/L]、血尿素氮[(9.32±1.12)μmol/L]、24h尿蛋白[(0.12±0.01)g]、AST[(33.31±3.58)U/L]、ALT[(32.48±3.41)U/L]明显低于对照组,血红蛋白[(117.76±11.98)g/L]、内生肌酐清除率[(101.28±10.33)mL/min]、总蛋白[(69.82±7.32)g/L]、清蛋白[(38.75±4.23)g/L]明显高于对照组。结论小柴胡汤加减联合小剂量激素能够有效地改善肾功能、保护肝功能,对于提高治疗总体有效率具有积极意义。Objective To study the short term efficacy and the biochemical indexes of modified Xiaochaihu De- coction combined with small dose of hormone for conducting the multiple targets therapy on refractory nephrotic syn- drome. Methods The patients with refractory nephrotic syndrome were selected and randomly divided into the obser- vation group treated by the multi target therapy of modified Xiaochaihu Decoction combined with small dose of hor- mone and the control group treated by the multi-target therapy of low dose hormone. The curative efficacies were ob- served. The renal function indexes of serum ereatinine, blood urea nitrogen, hemoglobin, endogenous creatinine clear- ance rate and 24 h urinary protein, and th .~ liver function indexes of albumin, globulin, aspartate aminotransferase （AST） ,alanine aminotransferase（ALT） were detected. Results Ihe total effective rate in the observation group was 88.330%, the curative effect was obviously better than that in the control group; serum creatinine[（272. 83±23. 52） μmol/L], blood urea nitrogen[（9.32±1.12）μmol/L] ,24 h urinary protein[（0.12±0.01） g], AST[（33.31±3.58） U/L], ALT[ （32.48±3.41 ）U/L] in the observaqtion group were significantly lower than those in the control group; while hemoglobin[ （117.76 ± 11.98 ） g/L], endogenous creatinine clearance rate [ （ 101. 28 ±10. 33 ） mL/min], total protein[（69.82±7.32）g/L] and albumin[（38.75±4.23）g/L] in the observation group were significantly higher than those in the control group. Conclusion Modified Xiaochaihu Decoction combined with small dose of hormone can effectively improve the renal function,protect the liver function and has the active significance to improve the o- verall effective rate for treating refractory nephrotic syndrome.

关 键 词：肾病综合征 小柴胡汤 激素治疗 

分 类 号：R725.9[医药卫生—儿科]