奈达铂联合放射治疗对老年食管癌患者的疗效观察  

Therapeutic Effect of Nedaplatin Combined with Radiotherapy for Elderly Patients with Esophageal Carcinoma

作　　者：龙国贤[1] 吴洁 石磊[1] 刘顺芳[1] 胡广原[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,武汉430030 [2]武汉市劳动教养管理局育新医院,武汉430015

出　　处：《医药导报》2014年第1期54-56,共3页Herald of Medicine

摘　　要：目的观察奈达铂联合放射治疗(放疗)对老年无法手术切除食管癌患者的疗效和安全性。方法老年无法手术切除食管癌患者36例,随机分为治疗组和对照组各18例。治疗组每周给予奈达铂35 mg·(m2)-1,同时联合放疗,原发灶和区域淋巴结剂量为60 Gy,30次,共6周。对照组采用相同剂量单纯放疗。观察两组近期疗效和毒副反应。结果治疗组和对照组客观缓解率分别为83.3%,61.1%(P<0.05)。治疗组白细胞下降、恶心呕吐和放射性食管炎发生率较对照组高(P<0.05),但3或4级毒性少见。结论奈达铂联合同步放疗治疗老年无法手术切除食管癌能显著改善近期疗效,毒副反应可耐受。Objective To evaluate the efficacy and safety of nedaplatin combined with radiotherapy on elderly patients with unresectable esophageal carcinoma. Methods A total of 36 patients with unresectable esophageal carcinoma were randomly divided into study group and control group, each group has 18 patients. The study group received coneun＇ent chemotherapy with nedaplatin 35 mg· （m2 ） i weekly combined with radiotherapy. The control group received radiotherapy only. Response rate and adverse event of both groups was evaluated. Results The response rate in study group was 83.3% , which was superior to that in the control group （61. 1% , P〈 0.05 ）. The incidence of leukoeytopenia, nausea and vomiting, and radiation esophagitis in the study group was higher than that in the control group （ P〈0. 05 ）. Adverse events of grade 3 or 4 were. rare. Conclusion Nedaplatin combined with radiotherapy could improve short-term effects and is well tolerated for elderly patients with unresectable esophageal carcinoma.

关 键 词：奈达铂 癌 食管 化学治疗 放射治疗 

分 类 号：R979.1[医药卫生—药品] R735.1[医药卫生—药学]