哌替啶及丙帕他莫与β-内酰胺类药物配伍实验  

Compatibility Test of β-lactams with Pethidin and Propacetamol

作　　者：杨舜娟[1] 林淑瑜[1] 潘丹婷[1] 甘惠贞[1] 

机构地区：[1]解放军第180医院药学科,福建泉州362000

出　　处：《医药导报》2014年第1期108-110,共3页Herald of Medicine

基　　金：南京军区医药卫生科研项目(10MA085)

摘　　要：目的探讨微量输液泵内哌替啶及丙帕他莫与β-内酰胺类药物在双通道输液管中出现白色结晶的原因。方法通过对相同药物配伍进行重复和模拟实验来寻找配伍禁忌的原因。结果输液泵中哌替啶在双通道中遇到β-内酰胺类药物会产生白色浑浊;注射用丙帕他莫不稳定,分解产物导致输液的pH降低,配伍3 h后输液的pH为3.34,溶液遇到β-内酰胺类药物等不耐酸性的药物开始发生配伍变化,在24 h内输液的pH从5.37逐渐降至1.87,配伍液由无色澄清变为白色结晶。结论输液泵中注射用丙帕他莫不宜长时间慢速滴注,应单独使用输液管路。含有哌替啶的输液泵液体不宜使用多通道管路输液器与β-内酰胺类药物同时进行输注,应单独使用输液管路。Objective To explore the reason for white c,＇ystalline development in dual-channel infusion tube when combing β-1actams with pethidin and propacetamnl in the micro-infusion pump. Methods The reason of incompatibility was explored by repeated simulating tests for the same drugs＂ combination. Results The white precipitation occurred in the dual- channel infusion tube when pethidine encountered β-lactams. Propacetamol for injection was unstable. Decomposition products of propacetamol lowered pH of the infusion to 3.34 after drug combining for three hours. After the acid nonresistant drugs such as β- lactams were added to the infusion liquid, with pH dropped from 5.37 to 1.87 over 24 h, and white crystals gradually developed. Conclusion Propacetamol in the infusion pump should not be used as intravenous drip for a long time. If used, propacetamol should be infused alone. The infusion pump liquids containing Pethidine should not be infused withβ-lactams simultaneously in the multi-channel infusion tube.

关 键 词：哌替啶 丙帕他莫 Β-内酰胺类药物 配伍禁忌 

分 类 号：R971.2[医药卫生—药品] R978[医药卫生—药学]