姜黄素对羟自由基及红细胞氧化性溶血的影响  

Effects of curcumin on hydroxyl free radical and the oxidative hemolysis in erythrocytes

作　　者：王建舜 容维祺 康九红[3] 

机构地区：[1]甘肃省武威地区人民医院,武威733000 [2]甘肃省平凉地区人民医院,平凉744000 [3]兰州大学生物系,兰州730000

出　　处：《中国现代应用药学》2000年第6期469-471,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :探讨姜黄素 (Curcumin ,Cur)清除羟自由基及防御脂质过氧化的能力。方法 :利用Fenton反应生成羟自由基 (OH) ,由AAPH诱发红细胞氧化性溶血。结果 :姜黄素对羟自由基有较强的清除作用 (SC50 为 58.8μmol/L) ,其作用超过OH的特异性清除剂甘露醇 (SC50 为 2 1 .3μmol/L) ;姜黄素 ( 1 2 0 μmol/L)能有效地抑制由AAPH诱发的红细胞氧化性溶血 (抑制 2h以上 ) ,显示了较强的防御脂质过氧化的能力。结论OBJECTIVE:To study the effect of curcumin(Cur) on hydroxyl free radical(OH) and oxidative hemolysis in mouse erythrocytes.METHODS:To produce the OH by fenton reaction and induce the oxidative hemolysis in mouse erythrocytes by AAPH.RESULTS:Cur was found to significantly scavenge the OH(SC 50 =58.8μmol/L),and the scavenging effect of Cur was obviously stronger than that of mannitol,a specific OH scavenger(SC 50 =21.3μmol/L).Cur(120μmol/L) was also shown to have strong inhibitory effect on erythrocytes oxidative hemolysis(the hemolysis was inhibited for more than 2h).CONCLUSION:It suggested that the anticancer and antiinflammation activity of Cur,may be related to its scavenging effects on oxygen free radicals and the inhibitory effect on lipid peroxidation.

关 键 词：姜黄素 羟自由基 红细胞溶血 

分 类 号：R931.71[医药卫生—生药学]