重症急性肾功能衰竭应用CRRT比照IHD的效果研究  

作　　者：邹懿[1] 王明初[1] 程宗华[1] 洪艳玲[1] 赵素[1] 姚国媛[1] 

机构地区：[1]泸州市人民医院肾脏内科,四川646000

出　　处：《当代医学》2014年第2期3-4,共2页Contemporary Medicine

摘　　要：目的对比重症急性肾功能衰竭应用连续性肾脏替代治疗及间歇性血液透析治疗的效果。方法根据患者对治疗方法的遴选意愿分为研究组16例和对照组16例。临床组应用连续性肾脏替代治疗,对照组应用间歇性血液透析治疗。对比两组低血压及心律失常诱发次数,KT/V值,24 h尿量达到600 mL时所经过的天数,并统计死亡人数及死亡率。结果临床组尿素氮治疗前为(38.56±12.26)mmol/L、治疗后为(20.04±6.01)mmol/L,尿肌酐治疗前为(825.31±262.47)mmol/L、治疗后为(402.42±122.14)mmol/L,APACHE-II评分治疗前为(21.4±4.36),治疗后为(14.1±5.37)。对照组尿素氮治疗前为(40.55±11.63)mmol/L、治疗后为(26.21±6.74)mmol/L,尿肌酐治疗前为(729.52±212.64)mmol/L、治疗后为(366.87±101.22)mmol/L,APACHE-II评分治疗前为(19.5±3.02),治疗后为(17.2±4.22)。在治疗后,两组尿素氮、尿肌酐及APACHE-II评分优化性改善非常显著,差异有统计学意义(P<0.05)。临床组低血压发作次数平均(3.72±1.29)次,心律失常发作次数平均(1.36±2.51)次,KT/V平均值为(1.41±0.13,24)h尿量达到600 mL所经过天数平均值为(15.21±5.13),死亡1例,死亡率为6.25%。对照组低血压发作次数平均(1.88±0.26)次,心律失常发作次数平均(3.73±3.22)次,KT/V平均值为(1.24±0.15),24h尿量达到600 mL所经过天数平均值为(22.64±8.26),死亡1例,死亡率为6.25%。临床组治疗后低血压及心律失常发生次数显著低于对照组(P<0.05),其KT/V值显著优于对照组(P<0.05),其24 h尿量达到600 mL所需天数明显少于对照组(P<0.05),两组死亡率差异无统计学意义(P>0.05)。结论重症急性肾功能衰竭应用连续性肾脏替代治疗的效果优于间歇性血液透析治疗。Objective To compare the treatment of severe acute renal failure with continuous renal replacement therapy and intermittent hemodialysis therapy. Methods According to the patients for treatment selection will be divided into study group 16 cases and control group with 16 cases. Clinical application of continuous renal replacement therapy, the control group using intermittent hemodialysis. Comparing the two groups of hypotension and arrhythmia induction frequency, KT/V value, the number of days after 24 h urine volume reaches 600 mL, and the death toll and mortality. Results The clinical group of urea nitrogen before treatment was （38.56±12.26）mmol/L, （20.04±＋6.01）mmol/L after treatment, urinary creatinine before treatment was （825.31 ±262.47）retool/L, （402.42±122.14）mmol/L after treatment, APACHE-II score before treatment was （21.4±4.36）, （14.1±5.37） after treatment. The control group of urea nitrogen before treatment was （40.55±11.63）retool/L, （26.21±6.74）mmol/L after treatment, urinary creatinine before treatment was （ 729.52±212.64 ） mmol/L, （ 366.87± 101.22 ） mmol/L after treatment, APACHE-II score before treatment was （19.5±3.02）, （17.2±4.22） after treatment. After treatment, two groups of urea nitrogen, creatinine and APACHE-If score optimization improvement is very significant, the difference was statistically significant （P〈0.05）. Episode number average （3.72±1.29） clinical groups hypotension episodes, with an average of （1.36±2.51） arrhythmia, the average value of KT/V by an average of （15.21±5.13） days was （1.41±0.13）,24 h urine volume reached 600 mL, 1 people died, the mortality was 6.25%. The control group hypotensive episodes with an average of （1.88±0.26） times, with an average of （3.73±3.22） episodes of arrhythmia, the average value of KT/V by an average of （22.64±8.26） days was （1.24±0.15）,24 h urine volume reached 600 mL, 1 people died, the mortality was 6.25%, Clinical treatment of hypoten

关 键 词：重症急性肾功能衰竭 连续性肾脏替代治疗 间歇性血液透析治疗 

分 类 号：R692.5[医药卫生—泌尿科学]