微波辐射下N-取代-1,8-萘内酰亚胺的合成研究  

The Research on Microwave-Assisted Synthesis of N-Alkyl-1H-Benzo[c,d]Indol-2-Ones

作　　者：张小兰[1] 汪秋英[2] 吕英英[1] 高兆芬[1] 郑大贵[1] 

机构地区：[1]上饶师范学院江西省普通高校应用有机化学重点实验室,江西上饶334001 [2]江西师范大学化学化工学院,江西南昌330022

出　　处：《江西师范大学学报（自然科学版）》2013年第6期603-606,共4页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：江西省普通高校重点实验室科技计划(GJJ10733)资助项目

摘　　要：在微波辐射和氢化钠促进下，1，8-萘内酰亚胺和卤代物在N，N-二甲基甲酰胺中经N-烷基化反应合成了N-取代-1，8-萘内酰亚胺衍生物，反应在6—8min内完成，产率为87％-93％．该方法具有产率高、反应时间短、操作简便等优点．所有产物经核磁氢谱、红外光谱和元素分析表征．A series of N-alkyl-lH-benzo[ c, d] indol-2-ones were synthesized by N-alkylation reactions of 1H-benzo [ c, d ] indol-2-one and halogenated compounds in N, N-dimethylformamide in the presence of sodium hydride under microwave irradiation. The reactions were completed with 87% -95% yields in 6 - 8 min, and this procedure has the advantages such as high yields ,short reaction time and easy work-up. The target compounds were confirmed by their 1H NMR, IR and elemental analysis.

关 键 词：N-取代-1 8-萘内酰亚胺 卤代物 N-烷基化反应 微波辐射 合成 

分 类 号：O624.6[理学—有机化学]