圆叶节节菜的化学成分研究  

Chemical constituents of Rotala rotundifolia

作　　者：谭钦刚[1] 赖春华[1] 王恒山[2] 

机构地区：[1]桂林医学院,广西桂林541004 [2]广西师范大学,广西桂林541004

出　　处：《广西植物》2013年第6期870-873,816,共5页Guihaia

基　　金："973"计划前期研究专项(2011CB512005);国家自然科学基金(81260472);广西自然科学基金(2012GXNSFBA053085)

摘　　要：从圆叶节节菜地上部分乙酸乙酯层中分离得到8个化合物,经波谱学方法分别鉴定为pomolic acid3β-acetate(1),7-oxo-β-sitosterol(2),6β-hydroxystigmast-4-en-3-one(3),esculetin(4),phyllemblin(5),1,2-O-digalloylglycerol(6),apigenin(7),quercetin(8),以上化合物均为首次从该植物中分离得到。化合物(6)在GK,SIRT1激动活性及DPPIV,11β-HSD抑制活性等抗糖尿病体外活性测试中均无明显的活性。Eight compounds were isolated from the ethyl acetate extraction of the aerial parts of Rotala rotundifolia,which were identified as pomolic acid 3β-acetate（1）,7-oxo-β-sitosterol（2）,6β-hydroxystigmast-4-en-3-one（3）,esculetin（4）,phyllemblin（5）,1,2-O-di-galloylglycerol（6）,apigenin（7）,and quercetin（8） by spectra analysis,and all of them were obtained from this species for the first time. Compound 6 showed no activity against glucokinase,SIRT1,DPPIV,11β-HSD in vitro anti-diabetes screening tests.

关 键 词：圆叶节节菜 化学成分 葡萄糖激酶 二肽基肽酶IV 11Β-羟基类固醇脱氢酶 糖尿病 

分 类 号：R284.2[医药卫生—中药学]