乙醇介质中简单高效合成吡喃并[3,2-c]吡啶衍生物（英文）  

A simple and efficient approach to the synthesis of pyrano[3,2-c]pyridines in ethanol

作　　者：王凯[1,2] 李玉玲 姜秋石 陈才法 

机构地区：[1]江苏师范大学化学化工学院 [2]功能材料绿色合成重点实验室,江苏徐州221116

出　　处：《江苏师范大学学报（自然科学版）》2013年第4期40-46,共7页Journal of Jiangsu Normal University：Natural Science Edition

基　　金：Research supported by the National Natural Science Foundation of China(21104064,21172188);Research Grant from the Innova-tion Project for Undergraduate of Jiangsu Province(2012JSSPIT3190);Undergraduate of School of Chemistry&Chemical Engineering(HXKY2D201202)

摘　　要：在回流条件下以乙醇为反应介质,醋酸铵为催化剂,三组分一锅法合成了2-氨基-4-芳基-5-氧代-5,6-二氢-4 H-吡喃并[3,2-c]吡啶-3-甲腈.该方法具有操作简单、反应条件温和、反应时间短等优点.2-Amino-4-aryl-5-oxo-5,6-dihydro-4H-pyrano[3, 2-c] pyridine-3-carbonitriles have been synthesized by three-component one-pot condensation of aldehyde, pyridine-2,4-diol, and malononitrile in the presence of ammoni- um acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reac- tion time, and little environmental impact.

关 键 词：吡喃并[3  2-c]吡啶 多组分反应 醋酸铵 乙醇 

分 类 号：O626.3[理学—有机化学]