氟噻草胺的合成工艺改进  

Improvement on the Synthesis Process of Flufenacet

作　　者：周新建[1] 韩邦友[1] 李梅芳[1] 

机构地区：[1]江苏快达农化股份有限公司技术部,江苏如东226401

出　　处：《南通职业大学学报》2013年第4期95-98,共4页Journal of Nantong Vocational University

摘　　要：改进了除草剂氟噻草胺的合成工艺:以氨基硫脲为原料,与三氟乙酸环合生成2-氨基-5-三氟甲基-1,3,4-噻二唑,再经重氮化反应生成2-氯-5-三氟甲基-1,3,4-噻二唑,最后与2-羟基-N-(4-氟苯胺)-N-(1-甲基乙基)乙酰胺反应,经后处理得氟噻草胺。该工艺路线流程短、产品效率高、含量高、三废少且反应条件温和,易于操作和控制,适合工业化生产。文章还对主要因素的影响进行了实验与分析。The paper studied on the flufenacet＇s synthesis process, which is greatly improved： aminothiourea is taken as the raw materials, cyclized with trifluoroacetic acid to generate 2-amino-5-trifluoromethyl-1, 3, 4-thiadiazol, then the product 2-chloro-5-trifluoromethyl-1, 3, 4-thiadiazole is got through diazotization, fi- nally reacted with 2-hydroxy-N-（4-fluorophenyl）-N-（isopropyl） acetamide to generate flufenacet after treat- ment. The route is suitable for the industrial production with the characteristics of short process, high efficacy and yields, mild reaction condition, which is conducive to operate and control.

关 键 词：氟噻草胺 合成路线 工业化生产 

分 类 号：S482.46[农业科学—农药学]