2,2'-联咪唑并[5,6-f]邻菲罗啉及其铜配合物的合成  

The Synthesis of 2,2'-bisglyoxaline [5,6-f] phenanthroline and its Copper Complexes

作　　者：孙允凯[1] 阳鹏飞[1] 梁俊[1] 陈民[1] 

机构地区：[1]南华大学化学化工学院,湖南衡阳421001

出　　处：《南华大学学报（自然科学版）》2013年第4期82-85,共4页Journal of University of South China：Science and Technology

基　　金：国家自然科学基金资助项目(11305086);博士启动基金资助项目(2011XQD55)

摘　　要：邻菲罗啉衍生物的金属配合物对于DNA具有键合作用,有助于研发抗癌新药.以1,10-邻菲罗啉为原料合成了1,10-邻菲罗啉-5,6-二酮,然后与2-咪唑醛和醋酸铵在冰乙酸的环境下加热回流3.5 h,得到产品2,2'-联咪唑并[5,6-f]邻菲罗啉.将该产物与硝酸铜配位,制得铜配合物.用NMR、元素分析和IR对产物进行了表征.该目标产物有可能对DNA的切割起作用.The metal complexes of phenanthroline ramification can bind to DNA through noncovalent interactions,which will help develop new anticancer drugs. 1,10-phenanthro- line-5,6-dione （DIONE） was synthesized by oxidation of 1,10-Phenanthroline. 2,2＇-bisg- lyoxaline[-5,6-f] phenanthroline （BGP） was then obtained by heating the mixture of DI- ONE / 2-imidazolecarboxaldehyde / ammonium acetate and glacial acetic acid to reflux. At last, copper complex of BGP was obtained by coordination reaction, which was BC, P charac- terized by IR, and all products were characterized by elemental analysis, NMR spectroscopy e and IR. The target product may have activity on DNA.

关 键 词：1 10-邻菲罗啉-5 6-二酮 2-醛基咪唑 合成 配合物 

分 类 号：O626.32[理学—有机化学]