地佐辛注射液用于缓解术后疼痛的有效性和安全性  

Efficiency and safty of dezocine injection for postoperative pain relief

作　　者：李然[1] 许幸[1] 

机构地区：[1]北京大学第一医院麻醉科,北京100034

出　　处：《中国临床药理学杂志》2014年第1期3-5,35,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究常用剂量的地佐辛静脉注射液对术后自控镇痛的有效性和安全性。方法选择拟全麻行择期手术患者,根据手术部位分为开腹、开胸、下肢3组。术后患者用自控静脉镇痛(PCA)方法注射地佐辛。观察镇痛后的疼痛视觉模拟评分(VAS)及药物不良反应。结果开腹组、开胸组和下肢组分别完成病例数是81,80,59例。术后2 h,开腹组和开胸组在咳嗽时的VAS高于下肢组。术后24 h和术后48 h,开胸组在静息和咳嗽状态VAS分值最高。3组静息时VAS平均值均在38 mm或以下。最常见的药物不良反应是恶心呕吐,其次是嗜睡;皮肤瘙痒罕见。结论地佐辛PCA给药可以满足开腹、开胸、3组下肢3种类型手术的术后镇痛需要,3组比较下肢镇痛疗效最好。controlled Objective To study the usual dose of dezocine for patient - analgesia after surgery, and to make the efficiency and safty e- valuation. Methods Patients aged 18 to 65 years old, having elective surgery, were divided into laparotomy, thoracotomy or lower limb ortho- pedic groups according to the surgical site. In all proups, postoperative pain was managed by patient- controlled analgesia （PCA） with dezo- cine. The resting and coughing Visual analogue scales （VAS） after the start of PCA 2 h, 6 h, 24 h and 48 h were recorded. The occurrences of adverse reactions were recorded. Results Laparotomy group, thoracoto- my group and lower limb orthopedic group completed 81 cases, 80 eases and 59 cases, respectively. After the start of PCA 2 h, coughing VAS in laparotomy group and thoracotomy group are higher than those in lower limb orthopedic group. After the start of PCA 24 h and 48 h, whether in resting or coughing, VAS of thoracotomy group was the highest. In all groups, the average resting VAS is 38 mm or less. Most common adverse reactions were nausea and vomiting, followed by drowsiness. Skin itching was rare. Conclusion PCA with dezoeine can meet the need of postop- erative analgesia after laparotomy, thoracotomy or lower limb orthopedic surgery. The analgesic effect of the lower limb orthopedic surgery is the best.

关 键 词：地佐辛 镇痛药 阿片类 术后镇痛 

分 类 号：R971.2[医药卫生—药品] R619[医药卫生—药学]