蒺藜对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响  

Effect of Tribulus terrestris on Testosterone Content,Substance Metabolism and Exercise Capacity of Rats after Exercise Training

作　　者：崔笑梅[1] 曹建民[2] 周海涛[3] 

机构地区：[1]兰州理工大学,兰州730050 [2]北京体育大学,北京100084 [3]北京联合大学生物化学工程学院,北京100023

出　　处：《中国实验方剂学杂志》2014年第3期157-161,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市属高等学校人才强教计划资助项目PHR201107150

摘　　要：目的:研究蒺藜对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响。方法:以大强度耐力训练大鼠为模型,65只42 d龄雄性Wistar大鼠为对象,随机分为5组:静止对照组(C组)、运动对照组(T组)、运动+低剂量蒺藜组(TML组)、运动+中剂量蒺藜组(TMM组),运动+高剂量蒺藜组(TMH组)每组12只(剔除不符合实验要求的大鼠)。每天ig给药1次,蒺藜组剂量分别为0.5,1,3 g·kg-1,ig体积为5 mL·kg-1,C组、M组ig等量生理盐水。49 d力竭游泳训练后,测定体重、力竭游泳时间及血睾酮等生化指标。结果:蒺藜各剂量组体重小于C组(P<0.05),大于T组(P<0.05);力竭游泳时间长于C组和T组(P<0.01);血清睾酮低于C组(P<0.05),高于T组(P<0.01);血清皮质酮水平各组间均无显著差异,各组间血清睾酮与皮质酮比值变化与睾酮变化较为一致;肝糖原(P<0.05)、肌糖原(P<0.01)高于C组和T组;促卵泡激素无明显影响;血尿素氮高于C组(P<0.05),低于T组(P<0.05);血红蛋白低于C组(P<0.05),高于T组(P<0.05)。结论:蒺藜可以减轻大鼠血睾酮受高强度运动量的影响,并维持在正常生理水平;可以促进蛋白质合成,抑制氨基酸和蛋白质分解,提高运动训练大鼠血红蛋白含量和糖原的储备。Objective： To study the effects of Tribulus terrestris on the content of testosterone, substance metabolism and anti-fatigue ability of rats. Method： By using the model of high-intensity endurance training, Sixty-five male Wistar rats were divided into 5 groups, 12 in each group, including control group （C group）, motion control group （T group） , exercise ＋ ig low-dose T. terrestris group （TML group） , exercise ＋ ig middle-dose T. terrestris group （TMM group）, and exercise ＋ ig high-dose T. terrestris group （TMH group）. Gavage was performed once a day. The rats in T. terrestris groups were gavaged with 0.5, 1 , 3 g .kg-1. The rats in C and T groups were given saline of same volume. After 49 days of exhaustive swimming training, body weight, swimming time and serum testosterone and other biochemical markers were measured. Result： The body weight of the rats in T. terrestris groups was less than C group （P 〈0.05）, greater than those in T group （P 〈0.05）, and theswimming time was longer than C and T group （P 〈 0.01 ）. The serum testosterone was lower than group C （P 〈 0. 05）, higher than the T group （P 〈 0.01 ）. Changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. Liver glycogen and muscle glycogen were higher than in C and T group （P 〈 0.05 or P 〈 0.01 ）. Blood urea nitrogen （BUN） was higher than C group （P 〈 0.05 ）, lower than theTgroup （P〈0.05）; hemoglobin was lower than C group （P〈0.05）, higher than the T group （P〈 0.05）. Conclusion： T. terrestris can alleviate the impact of high-intensity exercise on serum testosterone, and maintain it at normal physiologicaX levels; it can also promote protein synthesis, inhibit degradation of amino acid and protein, and increase hemoglobin and glycogen reserves in rats exercise training.

关 键 词：蒺藜 睾酮 抗疲劳 促黄体生成素 促卵泡刺激素 

分 类 号：R285.5[医药卫生—中药学]