苏黄止咳胶囊治疗慢性支气管炎急性发作期临床观察  

Suhuang Zhike Capsule in the Treatment of Acute Exacerbation of Chronic Bronchitis Clinical Observation

作　　者：许建新[1] 王洪玉[1] 郭欣[1] 

机构地区：[1]天津市泰达医院呼吸感染科,天津300457

出　　处：《中国实验方剂学杂志》2014年第3期186-189,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：天津市应用基础及前沿技术研究项目(10JCYBJC13700)

摘　　要：目的:探讨苏黄止咳胶囊治疗慢性支气管炎急性发作期的临床疗效及对炎性因子的影响。方法:将120例患者随机按数字法分为对照组和观察组各60例。对照组服用阿莫西林胶囊,0.5 g/次,3次/d,盐酸氨溴索片,30 mg/次,2次/d,饭后服用。观察组在对照组治疗的基础上加服苏黄止咳胶囊,3粒/次,3次/d。两组疗程均为10 d。记录治疗前咳嗽等主要症状、体积评分;记录咳嗽、咯痰、喘息及肺部啰音消失或转为轻度时间;检测治疗前后白细胞介素-6(IL-6),白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平。结果:观察组总有效率100%,优于对照组的83.35%(P<0.05);治疗后两组咳嗽、咯痰、喘息、肺部啰音等主要症状、体征评分及总分均显著下降(P<0.01),观察组除发热外,其余各主要症状、体征评分及总分均低于对照组(P<0.01);观察组咳嗽、咯痰、喘息及肺部啰音消失减轻/消失时间少于对照组(P<0.01);两组血清IL-6,IL-8,TNF-α水平均较治疗前明显下降(P<0.01),观察组血清IL-6,IL-8,TNF-α水平低于对照组(P<0.01)。结论:苏黄止咳胶囊能快速减轻慢性支气管炎急性发作期患者主要临床症状、体征,改善临床症状,提高临床疗效,其作用机制可能与降低血清IL-6,IL-8,TNF-α等炎性因子,减轻气道炎性损伤有关。Objective： To discuss the clinical efficacy of Suhuang Zhike capsule on acute exacerbation of chronic bronchitis and the effect on inflammatory factor. Method ： One hundred and twenry patients were randomly divided into observation group （n =60） and control group （n =60）. Control group was given amoxil capsule, 0.5 g each time, 3 time each day, and ambroxol hydrochloride tablet, 30 mg each time, 2 time each day, which were taken after meal. Suhuang Zhike capsule was added to observation group on the basis of control group, 3 capsules each time, 3 times each day. The two groups were treated for 10 days. The cardinal symptoms such as cough and symptom scores were recorded. The time when cough, cough up phlegm, wheeze and pulmonary rale disappeared or turned to be mild was recoreded, interleukin-6 （IL-6）, interleukin-8 （IL-8） and tumor necrosis factor-α （TNF- α） were tested. Result： The total effective rate of observation group （100%） were superior to control group （83.35%） （P 〈0.01 ） ; the symptom scores and the cardinal symptom such as cough, cough up phlegm, wheeze and pulmonary rale of both groups were descended （P 〈0.01 ） , and the symptom scores and the cardinal symptom except fever of observation group were lower than control group （P 〈 0. 01 ） ; the time when cough, cough up phlegm, wheeze and pulmonary rale disappeared or turned to be mild of observation group were less than control group （P 〈 0.01 ） ; the level of IL-6, IL-8, TNF-α of both groups were descended than before （P 〈 0.01 ）, andthe level of IL-6, IL-8, TNF-α of observation group were lower than control group （P 〈 0.01 ）. Conclusion： Suhuang Zhike capsule can rapidly relieve the cardinal symptoms of patients with acute exacerbation of chronic bronchitis, improve the clinical symptoms, enhance clinical effects. The mechanism maybe relate to the reduction of the level of IL-6, IL-8, TNF-a in serum and the alleviation of inflammatory damage to air passage.

关 键 词：慢性支气管炎 急性发作期 苏黄止咳胶囊 白细胞介素-6 白细胞介素-8 肿瘤坏死因子-α 

分 类 号：R287[医药卫生—中药学]