合欢皮抗抑郁作用研究  

Study on Antidepressant Effect of Albiziae Cortex in Mice

作　　者：廖颖[1] 王琼[1] 黎霞[1] 詹天骄 杨小芳[1] 江泳[2] 

机构地区：[1]四川师范大学生命科学学院,四川成都610101 [2]成都中医药大学,四川成都610075

出　　处：《安徽农业科学》2014年第1期57-58,共2页Journal of Anhui Agricultural Sciences

基　　金：四川师范大学校级青年项目(08QNL08)

摘　　要：[目的]研究合欢皮提取物的抗抑郁作用。[方法]采用小鼠悬尾试验、强迫游泳试验以及利血平所致小鼠抑郁模型试验观察合欢皮提取物的抗抑郁作用。[结果]给小鼠灌胃给予浓度100和300 mg/kg的合欢皮提取物均能缩短小鼠悬尾试验和强迫游泳试验累计不动时间,并能对抗利血平所致小鼠体温下降和眼睑下垂。[结论]合欢皮提取物对小鼠悬尾模型、强迫游泳模型和利血平所致抑郁模型表现出抗抑郁的作用。[ Objective ] To study the antidepressant effect of Albiziae Cortex extracts. [ Method ] Mouse tail suspension t^st, forced swimming test and reserpine -induced mouse depression model were used to evaluate the antidepressant effect of Albiziae Cortex extracts. [ Result] The extract of Albiziae Cortex significantly shortened disappointment time in mouse tail suspension test, forced swimming test and antagonized the ptosis and hypothermia in reserpine induced mouse depression model. [ Conclusion] Extract of Albiziae Cortex had some antidepressant effect in mouse tail suspension test, forced swimming test and reserpine- induced mouse depression model.

关 键 词：合欢皮(CORTEX ALBIzIAE) 抗抑郁作用 悬尾试验 强迫游泳试验 

分 类 号：S253[农业科学—农业机械化工程]