老年住院患者肾功能情况调查分析  

Analysis of renal function state in aged inpatients

作　　者：刘伟[1] 林杏娥[1] 余枫[1] 陈剑[1] 钱芸娟[1] 郝文科[1] 

机构地区：[1]广州广东省人民医院广东省医学科学院肾内科,广东510080

出　　处：《国际泌尿系统杂志》2014年第1期26-30,共5页International Journal of Urology and Nephrology

摘　　要：目的 了解老年住院患者肾功能情况及肾功能下降的危险因素.方法 回顾性分析年龄≥60岁的患者资料,收集肾损伤及相关临床资料,分析患者肾功能情况及相关危险因素.结果 在1051例患者中,平均eGFR为71.0±24.8mL· （min· 1.73m2）-1,肾功能下降的发生率为31.1％.60 ～69岁组、70～79岁组、80～ 89岁组和90岁以上组eGFR分别为83.4 ±28.4、72.2 ±22.9、67.8±24.3、58.8±29.1 mL·（min· 1.73m2）-1,而肾功能下降的发生率分别为12.8％、27.0％、37.8％和51.7％.Logistic回归分析显示,高尿酸血症、蛋白尿、泌尿系肿瘤、贫血、脑卒中、高血压病、肾囊肿、女性、冠心病和年龄是老年人肾功能下降的危险因素.结论 老年患者肾功能下降的发生率高,且随年龄增大而增高,积极控制相关危险因素将有助于延缓老年患者肾功能下降.Objectives To investigate the renal function state and risk fators of reduced renal function among aged inpatients.Methods The clinical data of inpatients aged 60 years or over were collected.The estimated glomerular filtration rate（eGFR） was calculated by abbreviated MDRD equation.The renal function state and risk fators of reduced renal function were analyzed.Results In all 1051 subjects with eligible data,the mean eGFR was 71.0 ± 24.8 ml · （min · 1.73m2）-1 and the incidence rate of reduced renal function was 31.1％,the incidence rates of proteinuria,hematuria and leucocyturia were respectively 11.8％,6.6％ and 8.7％.The eGFR values were respectively 83.4 ± 28.4,72.2 ± 22.9,67.8 ± 24.3 and 58.8 ± 29.1 ml · （min · 1.73m2） 1 in the group of 60-69,70-79,80-89 and ≥90 years old （F =15.101,P =0.000）,while the incidence rates of reduced renal function were separately 12.8 ％,27.0％,37.8％ and 51.7 ％ in the above age groups （x2 =36.143,P =0.000）.Binary logistic regression analysis showed that hyperuricemia （OR =4.62,P =0.000）,proteinuria （OR =3.96,P =0.000）,urinary tumor （OR =2.92,P =0.015）,anemia（OR =2.45,P =0.000）,stroke（OR =1.96,P =0.000）,hypertension （OR =1.83,P =0.006）,renal cyst （OR =1.64,P =0.018）,female （OR =1.54,P =0.015）,coronary artery disease （OR=1.53,P =0.008） and age（OR =1.05,P =0.000） were the risk factors of reduced renal function.Conclusions The incidence rates of reduced renal function was high in elderly patients and the eGFR values decreased by age,while the incidence rates of reduced renal function increased.Treatment and control of comorbidities might contribute to slow the decline of renal function.

关 键 词：肾疾病 肾小球滤过率 老年人 危险因素 

分 类 号：R692[医药卫生—泌尿科学]