口服结肠定位给药系统中辅料的应用  

Application of Excipients for Oral Colon-specific Drug Delivery System

作　　者：方勇兵 崔升淼[1] 

机构地区：[1]广东药学院,广东广州510006

出　　处：《中国医药工业杂志》2014年第1期83-87,94,共6页Chinese Journal of Pharmaceuticals

基　　金：广东药学院重点培养教师资助计划给予资助

摘　　要：口服结肠定位给药系统(OCDDS)具有结肠定位性、可提高局部药物浓度和直接作用于病灶部位等优点。正确选用辅料是获得结肠定位释放性能的关键。本文综述了丙烯酸树脂类、偶氮类和多糖类化合物等辅料在OCDDS中的应用进展,旨在为OCDDS的进一步研究提供参考。The oral colon-specific drug delivery system （OCDDS） has the advantages of colon-specific release property, increasing local drug concentration and acting on the lesion site directly, etc. The key point is the correct choice of excipients for OCDDS. The recent applications of some excipients, including Eudragits, azo-polymers and polvsaccharides for OCDDS are reviewed in this paper in order to provide a reference for the further research.

关 键 词：口服结肠定位给药系统 辅料 应用 综述 

分 类 号：R944.9[医药卫生—药剂学]