溴咖合剂对偏头痛模型小鼠大脑皮层神经递质含量的影响  

Effects of Xiuka mixture on neurotransmitter in cerebral cortex of model mice with migraine

作　　者：武延庆 戴余雯 李静[2] 刘铭佩[1] 白银亮[1] 

机构地区：[1]兰州大学第二医院药学部,甘肃兰州730030 [2]郑州大学药学院临床药学系,河南郑州450001

出　　处：《中国医院药学杂志》2014年第1期23-25,共3页Chinese Journal of Hospital Pharmacy

基　　金：中央高校基本科研业务费专项资金(编号:lzujbky-2013-46);河南省高校科技创新人才支持计划项目(编号:10PTGS484-20)

摘　　要：目的:观察溴咖合剂对偏头痛模型小鼠大脑皮层神经递质含量的影响。方法:建立利血平化低5-羟色胺(5-HT)小鼠偏头痛模型,采用热板法检测小鼠痛阈值,玻片法测定凝血时间;采用酶联免疫吸附法检测5-HT和多巴胺(DA)的含量。结果:溴咖合剂可明显提高偏头痛小鼠痛阈值,延长凝血时间,增加小鼠大脑皮质中5-HT和DA的含量,作用强度与麦角胺咖啡因片相当。结论:溴咖合剂能改善偏头痛发作时大脑皮层神经递质活动失常,从而缓解偏头痛症状。OBJECTIVE To investigate the effects of Xiuka mixture on neurotransmitter in cerebral cortex of model mice with migraine.METHODS Mice model with migraine caused by exhausting 5-hydroxytryptamine（5-HT）with reserpine was built up,pain threshold in mice was evaluated using hot plate assay,clotting time was determined by slide method;The level of 5-HT and DA of mice was tested with Elisa assay.RESULTS Xiuka mixture could increase pain threshold and clotting time in mice,also could increase the content of 5-HT and DA in cerebral cortex of model mice with migraine.The effect of Xiuka mixture was similar to that of ergotamine caffeine tablet.CONCLUSION Xiuka mixture can improve cerebral cortex neurotrans-mitter activity disorders,thus easing the symptoms of migraine.

关 键 词：溴咖合剂 偏头痛 小鼠 5-羟色胺 多巴胺 

分 类 号：R965[医药卫生—药理学]