儿童重症肺炎血促胃液素、胃动素及胰岛素样生长因子-1水平变化临床意义  

The clinical significance of variations in serum levels of gastrin, motilin and insulinoid growth factor-1 among children with severe pneumonia

作　　者：王凤枝[1] 彭广飞[1] 

机构地区：[1]漯河医学高等专科学校,河南漯河462002

出　　处：《现代预防医学》2014年第2期230-232,共3页Modern Preventive Medicine

摘　　要：目的探讨重症肺炎儿童血促胃液素(GAS)、胃动素(MOT)及胰岛素样生长因子-1(IGF-1)水平的变化及临床意义。方法随机选取2010年2月-2012年6月符合诊断标准的重症肺炎30例,普通肺炎32例,同期健康体检儿童30例设为对照组。3组儿童均晨起空腹抽取静脉血,采用放射免疫方法检测GAS、MOT、IGF-1。结果重症肺炎组较普通肺炎组明显增高,普通肺炎组又高于对照组,差异有统计学意义(P均<0.01)。重症肺炎组GAS、MOT、IGF-1水平与PaO2呈直线负相关(P值分别<0.01,<0.05)。结论检测血GAS、M0T、IGF-1水平对儿童肺炎病情严重程度的评估及判断预后有重要的临床参考意义。Objective The study was conducted to establish the clinical significance of variations in serum levels of gastrin （GAS）, motilin （MOT） and insulinoid growth factor-1 （IGF-1） among children with severe pneumonia. Methods A total of 62 cases （30 children with severe pneumonia and 32 children with common pneumonia） were randomly selected from patients who were diag- nosed between February 2010 and June 2012 according to the diagnostic standards, while another 30 healthy children were selected as the control group. Fasting venous blood samples were collected from the children in the morning. Serum levels of GAS, MOT and IGF-1 in the blood samples were determined by radioimmunoassay. Results The serum levels of GAS, MOT and IGF-1 in the se- vere pneumonia group were distinctly higher than the common pneumonia group, while the serum levels of GAS, MOT and IGF-1 in common pneumonia group were higher than the control group. The differences were statistical significant between the three groups （P〈O.O1）. In addition, the serum levels of GAS, MOT and IGF-1 in the severe pneumonia group were negativnely correlated with PaO2 level （P〈O.01,/9〈0.05）. Conclusion Monitoring the serum levels of gastrin, motilin and insulinoid growth factor-1 is a infor- mative approach for evaluating the severity and prognosis of pneumonia in children.

关 键 词：重症肺炎 促胃液素 胃动素 胰岛素样生长因子-1 儿童 

分 类 号：R725.6[医药卫生—儿科]