湖南省郴州市2009——2011年手足口病流行病学特征研究  

Study on the epidemiological features of hand-foot-mouth disease(HFMD) in Chenzhou, Hunan between 2009-2011

作　　者：谭徽[1] 谢群[1] 何清懿[1] 刘爱平[1] 付敏[1] 陈白鹭[1] 

机构地区：[1]湖南省郴州市疾病预防控制中心,湖南郴州423000

出　　处：《现代预防医学》2014年第2期329-332,336,共5页Modern Preventive Medicine

基　　金：郴州市科技计划项目(CZ2013108)

摘　　要：目的了解湖南省郴州市2009—2011年手足口病流行病学特征和规律。方法采用描述性流行病学方法对郴州市2009—2011年手足口病监测数据进行分析，率和构成比的比较采用矿检验。结果郴州市2009—2011年报告发病率分别为32．47／10万，132．67／10万，111．92／10万。丘陵地区尤其是靠近市区的地区报告发病数较多；全年均有病例报告，但以15～32周为主，17～28周为发病高峰；发病以3岁及以下儿童为主；男性多于女性；重症（死亡）病例以3岁以下散居儿童为主。病原学监测结果显示，2009年和2010年均以HEV71为主（z2=19．13，P〈0．叭；矿=162．08，P〈0．01），2011年无明显优势病原体（矿=5．51，P〉0．05）。分离的HEV71阳性株，属C4a基因亚型。结论郴州市每年春夏季节，应加强3岁以下儿童手足口病的预防和控制，丘陵地区人口密集区的散居儿童是防控的重点。Objective The aim of this study was to understand the epidemiologic features and the pattern of hand-foot-mouth dis- ease （HFMD） in Chenzhou City from 2009 to 2011. Methods Descriptive epidemiological study was conducted to analyze the data obtained by monitoring incidents of HFMD in Chenzhou from 2009 to 2011, and chi-square test was used to compare corresponding rates and ratios. Results The annual incidence rates of HFMD in Chenzhou for 2009, 2010 and 2011 were 32.47/100 000, 132.67/100 000 and 111.92/100 000, respectively. More HFMD cases were reported in the hilly area and especially in the suburbs compared to other areas. The cases were reported throughout the year, but mainly from week 15 to 32, with peak occurrence ap- peared from week 17 to 28. The onset ages for patients mainly ranged from 0 to 3 years old. There were more male patients than fe- male ones. The severe or lethal cases were mainly reported in children who were less than 3 years old and live scattered. The results of pathogenic surveillance showed that the main pathogen was H EV71 in 2009 and 2010 （X~ 19.13, P〈0.O 1; ~= 162.08, P〈0.01）, while the main pathogen was not apparent in 2011 （Zz=-5.51, P〉0.05）. The isolated HEV71 positive strains belong to C4a genotypes. Conclusion In spring and summer, the prevention and control of HFMD in Chenzhou should be focused on children under 3 years old, and the action should also be emphasized on children live scattered in hilly areas and population-compact districts.

关 键 词：手足口病 流行病学 人肠道病毒71型 柯萨奇病毒A组16型 

分 类 号：R181.23[医药卫生—流行病学]