中药丹参、川芎嗪防治脑缺血实验研究  

Chinese Medicine Danshen,Sichuan Dome Oxazine Experiment Research of Prevention and Treatment of Cerebral Ischemia

作　　者：牛映雪[1] 鹿国晖[1] 刘杨[1] 

机构地区：[1]北京体育职业学院,北京100075

出　　处：《亚太传统医药》2014年第1期8-9,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:研究丹参、川芎嗪对沙土鼠脑缺血及脑水肿的作用。方法:将120只沙土鼠分为6组,分别给药,处死后即刻称量脑重,与体重相比计算出脑指数。部分样本取脑,进行石蜡包埋、切片、HE染色处理,然后进行病理观察。结果:静脉给药组的生存时间延长,脑指数降低。沙土鼠静脉注射伊文兰后,毛细血管通透性明显降低,与对照组相比有显著性差异。病理检查发现,给药组沙土鼠脑组织缺血的病理变化较轻。结论:丹参及川芎嗪能抑制脑内毛细血管通透性升高,对沙土鼠的脑缺血具有预防及治疗作用。Objective： To study the dome-triazine Salvia and the cerebral ischemia in gerbils and brain edema. Methods： 120 sand rat can be divided into 6 groups, respectively, executed immediately and weigh the weight of brain , and the ratio of the weight to calculate the index. Part of the specimen in brain, paraffin embedding, sectioning, HE staining, the pathological observation. Re- suits：Observation Group intravenous prolonged survival, brain down. Portland, intravenous Iraq, capillary permeability decreased significantly compared with the control group there were significant differences. Pathological examination revealed that the treatment group ischemic brain tissue pathological changes lighter. Conclusion： The results showed that Salvia and triazine-Qiong can inhibit brain capillary permeability increase, the cerebral ischemia in gerbils and brain edema role in the prevention and treatment.

关 键 词：中药 丹参 川芎嗪 缺血性脑水肿 

分 类 号：R285.5[医药卫生—中药学]