T细胞免疫球蛋白及黏蛋白域蛋白4在免疫反应与疾病中的作用  

Role of T cell immunoglobulin domain and mucin domain 4 in immune response and disease

作　　者：于雄伟 薄禄龙[1] 邓小明[1] 

机构地区：[1]第二军医大学附属长海医院麻醉科,上海200433 [2]河北邯郸市解放军第285医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2014年第1期79-82,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金青年基金项目（81201492）,（81201456）

摘　　要：背景T细胞免疫球蛋白及黏蛋白域蛋白（T cell immunoglobulin domain and mucin domain，TIM）家族能调节T细胞免疫反应。TIM4只表达在抗原递呈细胞表面。作为T细胞活化强有力的免疫共刺激分子，调控Th细胞的分化增殖。目的研究TIM4与其配体结合后调节T细胞免疫反应的机制，探究TIM4在疾病中的作用。内容TIM4的基础研究进展，TIM4在疾病中的研究进展。趋向TIM4对T细胞增殖的促进或抑制作用取决于其结合的配体和T细胞分化的程度。TIM4的表达异常与多种过敏性或自身免疫性疾病的发生有关，可能成为药物治疗的新靶点。Background T cell immunoglobulin domain and mucin domain （TIM） molecules can regulate T cell immune responses. TIM4 is exclusively expressed in APCs. As a strong immune costimulatory molecule in T cell activation, it can regulate Th cell proliferation and differentiation. Objective Clarify the mechanism of T cell immune response regulated by TIM4 and its ligands, and explore the role of TIM4 in disease. Content To review the recent advance of TIM4 molecule and the role of TIM4 in diseases. Trend The role of TIM4 in T cell proliferation and inhibition depend on its ligand and the stage of T cell differentiation. TIM4 regulated immune responses are associated with many kinds of diseases, making TIM4 a new target for therapy.

关 键 词：T细胞免疫球蛋白及黏蛋白域蛋白4 Th细胞活化 抗原递呈细胞 过敏反应 免疫耐受 

分 类 号：R392[医药卫生—免疫学]