糖尿病伴血管病变时血管内皮功能、纤溶活性及血小板活化的变化  

Changes of Endothelium Function,Fibrolysis Activity and Platelet Activation in Diabetic Angiopathies

作　　者：赵纯平[1] 李敬兰[1] 何秀玲[1] 封树庭[1] 曹金霓[1] 

机构地区：[1]天津市第一中心医院,300192

出　　处：《天津医药》2001年第2期71-72,共2页Tianjin Medical Journal

摘　　要：目的:观察DM患者无(A组)与有(B组)血管病变时的血管内皮功能、纤溶活性及血小板活化状态的变化。方法:vWF用免疫电泳法,TM和GMP-140用ELISA法,t-PA和PAI-1用发色底物显色法,PAgT比浊法。结果:(1)vWF:Ag、TM、PAI-1和GMP-1404项指标,DM及其两个亚组都高于对照组,B组高于A组。(2)t-PA,B组高于对照组和A组。(3)PAgT,仅见B组高于对照组。以上的差异均有显著性意义(P<0.05或P<0.01)。结论:(1)DM早期即有血管内皮细胞损伤,发生血管病变则增高更为显著。(2)DM凝血与纤溶调节处于较高水平,PAI-1相对升高,系诱发血栓形成的危险因素。(3)血浆GMP-140为反映血小板活化敏感的指标。Objective:To investigate the changes of endothelium function (vWF, TM), fibrolysis activity (t-PA, PAI-1), and platelet activity in patients with (group A) and without (group B) diabetic angiopathies. Method:vWF was detected by im-munoeletrophoresis.TM and GMP-140 were examined by ELISA. t-PA and PAI-1 were determined by chromogenic assay. PAgT was certained by turbidimetry. Results:The concentration of vWF,TM,PAI-1 ,and GMP-140 in blood were higher in both group A and group B than those in control group,and were higher in group B than those in group A. The concentration of t-PA was higher in group B than that in group A and control group. PAgT was higher in group B than that in control group (P< 0.05) . Conclusion: The vessel endothelia are damaged in the early phase of DM, and this damage is more serious in patients with angiopathies. The dangerous factor of thrombosis are high level of coagulation and fibrolysis, and increased PAI-1.GMP-140 is a sensitive indicator for platelet activation.

关 键 词：糖尿病血管病 血栓调节蛋白 T-PA PAI-1 血小板活化 

分 类 号：R587.2[医药卫生—内分泌]