遵义汉族人群降钙素受体基因多态性与强直性脊柱炎的关系  

The correlation between calcitonin receptor gene polymorphism and ankylosing spondylitis in Han population in Zunyi

作　　者：余晓[1] 肖代敏[2] 李学英[3] 张志敏[3] 张娅[2] 

机构地区：[1]遵义医学院生物化学教研室,贵州遵义563099 [2]遵义医学院附属医院检验中心,贵州遵义563099 [3]遵义医学院细胞生物学与遗传学教研室,贵州遵义563099

出　　处：《广东医学》2013年第24期3732-3734,共3页Guangdong Medical Journal

基　　金：贵州省卫生厅科学技术基金资助项目(编号:gzwkj2009-1-020)

摘　　要：目的探讨遵义汉族人群降钙素受体(CTR)基因1377位点(AluⅠ酶切位点)多态性与强直性脊柱炎(AS)的关系。方法收集109例遵义地区汉族人群静脉血标本,其中AS患者50例,正常对照者59例,用聚合酶链反应-限制性片段长度多态性法测定两组标本的CTR基因C1377T位点多态性,分析AS患者和正常对照者中基因型频率和基因频率分布规律,并分析CTR基因C1377T位点多态性与AS的关系。结果 AS患者中C1377T的等位基因频率为C 94%、T 6%;正常对照者中分布为C 93%、T 7%,两组等位基因频率分布差异无统计学意义(P>0.05)。结论 CTR基因C1377T位点多态性与遵义汉族人群的AS发病无关。Objective To investigate the correlation of Alu I polymorphism in 1377 loci of calcitonin receptor （CTR） gene with ankylosing spondylitis （AS） in Han population in Zunyi. Methods Blood samples were collected in 109 Han population in Zunyi area, including 50 AS patients and 59 healthy individuals （controls）. CTR gene C1377T polymorphism was tested by PCR -restriction fragment length polymorphism assay. The distribution of the genotypes and allele frequencies were analyzed for further correlation study. Results The frequencies of C and T in CTR gene C1377T alleles in AS patients were 94% and 6%, respectively; while were 93% and 7%, respectively in controls. Conclusion CTR gene C1377T polymorphism is not correlated with AS in Han population in Zunyi area.

关 键 词：降钙素受体基因 C1377T多态性 强直性脊柱炎 遵义汉族人群 

分 类 号：R681[医药卫生—骨科学]