老年冠心病患者血清脑钠肽的变化及临床意义  

作　　者：方堃[1] 叶炼[1] 赵政[1] 王芳[1] 

机构地区：[1]四川省科学城医院检验科,621900

出　　处：《内蒙古中医药》2013年第35期9-10,共2页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:观察不同类型冠心病患者血清脑钠肽(NT-proBNP)的变化,研究其与肌钙蛋白T(TNT)和肌酸激酶同工酶(CK-MB)的相关性,探讨其临床意义。方法:检测260例冠心病患者(包括稳定型心绞痛147例、不稳定型心绞痛78例、急性心肌梗死35例)的NTproBNP、TNT、CK-MB的水平,30例健康者作为对照组,比较不同组别NT-proBNP的差异及其与TNT、CK-MB的关系。结果:对照组、稳定型心绞痛组(SAP)、不稳定型心绞痛组(UAP)、急性心肌梗死组(AMI)的血清NT-proBNP浓度分别为(76.5±16.9)ng/L、(82.6±20.8)ng/L、(2168±366.7)ng/L、(6780±1025.6)ng/L,AMI组与其他组差异具有统计学意义(P<0.001)。AMI组NT-proBNP与TNT(P<0.001)、CK-MB(P<0.01)浓度变化呈正相关。结论:不同临床类型的NT-proBNP浓度存在差异,可作为冠心病临床分型指标,对疾病的预后观察具有重要意义,与心肌坏死程度相关。Objective ：To investigate the changes of serum NT-proBNP levels and explore the correlations with TNT and CK-MB in different types of patients with coronary atherosclerotic heart disease, also to probe the clinical values. Methods：Examine serum NT-proBNP, TNT, CK-MB in 260 patients （147 with stable angina pectoris, 78with unstable angina pectoris, 35 with acute myocardial infarction）, together with 30 healthy controls to compare the difference of NT-proBNP level and its relationships with TNT and CK-MB in each group. Results： The serum concentrations of healthy control, SAP, UAP and AMI group are respectively （76.5±16.9）ng/L, （82.6±20.8）ng/L, （2168±366.7） rig/L, （6780±1025.6）ng/L. The difference is statistically significant between AMI and other three groups, which NT-proBNP is positively re- lated with density changes of TNT（P〈0.001 ）and CK-MB（P〈0.01 ）. Conclusion： Sufferers of different clinical types have different NT-proBNP density and the level is relevant to the degree of myocardial necrosis. NT-proBNP may be a clinical classification index and has important significance in prognosis observations.

关 键 词：冠心病 血清脑钠肽 肌钙蛋白T 

分 类 号：R541.5[医药卫生—心血管疾病]