斑秃的研究进展  

Advances in alopecia areata

作　　者：谭欢[1] 杨希川[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《国际皮肤性病学杂志》2014年第1期46-48,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（30972648、81271771）

摘　　要：斑秃是一种由T淋巴细胞介导的针对毛囊的器官特异性自身免疫性疾病，正常毛囊的免疫赦免作用的破坏在其发病过程中起着重要作用。精神心理因素可使病情加重或反复。目前通过全基因组关联分析至少发现了8个与斑秃发病有关的基因区域，为更好地认识斑秃的发病机制和寻求新的治疗方法提供了遗传学的理论基础。斑秃的发病机制尚不完全清楚，了解斑秃的流行病学。Alopecia areata is considered as a T-cell-mediated, hair follicle-targeted autoimmune disease. The gradual loss of protection provided by hair follicle immune privilege plays an important role in the pathogenesis of alopecia areata. It can be induced or triggered by psychiatric and psychological factors. Recently, at least eight domains have been identified to be associated with alopecia areata by a genome-wide association study （GWAS）, which may provide a theoretical basis for the understanding of its pathogenesis and development of new therapeutic strategies. Now the pathogenesis of alopecia areata remains unclear, and available therapies are limited. To learn the epidemiology, etiology and treatment of alopecia areata may be beneficial to its management.

关 键 词：斑秃 流行病学 治疗学 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]