慢性荨麻疹发作期与缓解期凝血状态、补体以及炎症标志物水平的改变  

Determination of coagulation status as well as circulating levels of complement and inflammation markers in patients with chronic urticaria during acute attack and in remission stage

作　　者：梁碧华[1] 李润祥[1] 林路洋[1] 李振洁[1] 肖常青[1] 朱慧兰[1] 

机构地区：[1]广州市皮肤病防治所,510095

出　　处：《中华皮肤科杂志》2014年第1期30-32,共3页Chinese Journal of Dermatology

基　　金：基金项目：广东省自然科学基金（S20120200n077）;广州市医药卫生科技项目（20121A01i131）

摘　　要：目的探讨凝血因子、抗凝因子以及纤溶标志物与慢性荨麻疹（cu）发病的关系并分析CU在发作期与缓解期不同状态下凝血状态、补体水平以及炎症标志物水平改变的情况。方法40例CU患者中缓解期CU18例，发作期CU22例，来自广州市血液中心的健康献血员40例作为健康对照组，用ELASA等方法检测凝血酶原片段F1＋2（F1＋2）、组织因子（TF）、血栓调节蛋白（TM）、高分子量激肽原（HMwK）、组织型纤溶酶原激活剂（t—PA）、C5a、C3、C4、血细胞沉降率（ESR）、抗溶血性链球菌O（ASO）、C反应蛋白（CRP）、类风湿因子（RF）水平，观察上述指标在CU发作期以及缓解期的改变。结果与健康对照组相比，cu患者血浆F1＋2和HMWK水平明显升高（P〈0．01），而TF、TM和卜PA水平明显降低（P〈0．01）。CU患者的血浆F1＋2、HMWK以及t—PA水平与症状评分相关（r=0．81，P〈0．01；r=-0．39，P〈0．05；r=0．35，P〈0．05）。CU患者发作期血浆FI＋2水平较缓解期明显升高（P〈0．01）。TF、TM、HMWK、t-PA、C5a、C3、C4、ESR、ASO、RF、CRP水平在发作期与缓解期的差异均无统计学意义。结论凝血因子、抗凝因子以及纤溶标志物均参与CU发病。CU发作期与缓解期存在着F1＋2水平的明显差异，提示凝血因子可能在CU发生发展中起作用。Objective To determine the coagulation status as well as circulating levels of complement and inflammation markers in patients with chronic urticaria （CU） during acute attack and in remission, and to estimate the relationship of coagulant and anticoagulant factors as well as fibrinolytic markers with the development of chronic urticaira. Methods This study included 40 patients with CU （22 during acute attack and 18 in remission） and 40 healthy blood donors from the Guangzhou Blood Center. Venous blood samples were obtained from these subjects, and enzyme-linked immunosorbent assay （ELISA） was performed to measure the plasma levels of prothrombin fragment 1＋2 （Fl＋2）, tissue factor （TF）, thrombomodulin （TM）, high molecular weight kininogen （HMWK）, tissue-type plasminogen activator （t-PA）, C5a and serum levels of C3, C4, antistreptolysin O antibodies （ASO）, rheumatoid factor （RF） and C-reactive protein （CRP）. Erythrocyte sedimentation rate （ESR） was also determined in these patients. Comparisons of these parameters were carried out by using t test, and the correlation of these factors with CU was evaluated by using Spearman correlation coefficient. Results Compared with the healthy controls, the patients with CU showed significantly higher plasma levels of Fl＋2 and HMWK （both P 〈 0.01）, but lower levels of TF, TM and t-PA （all P 〈 0.01）. The plasma levels of F1＋2, HMWK, t-PA were significantly correlated with the symptom scores in patients with CU （r = 0.81, P 〈 0.01; r = -0.39, P 〈 0.05; r = 0.35, P 〈 0.05）. A significant increase was observed in the plasma concentration of Fl＋2 in patients during acute attack compared with those in remission （P 〈 0.01）, whereas no significant differences were noted in the plasma levels of TF, TM, HMWK, t-PA, CSa, serum levels of C3, C4, ASO, RF and CRP or ESR between the two groups of patients （all P 〉 0.05）. Conclusions It seems that coagulation, anti-coagulation and fibrinolysis are all i

关 键 词：荨麻疹 血液凝固 补体系统蛋白质类 炎症 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]