中波高能紫外线与308nm准分子激光治疗白癜风的短期疗效比较  

Short-term efficacy of high-inteusity ultraviolet B versus 308-nm excimer laser for the treatment ofvitiligo

作　　者：董达科[1] 杨莉佳[1] 陶诗沁[1] 吴家强[2] 项蕾红[2] 

机构地区：[1]南京医科大学附属无锡第二人民医院皮肤科,江苏无锡214002 [2]复旦大学附属华山医院皮肤科

出　　处：《中华皮肤科杂志》2014年第1期59-61,共3页Chinese Journal of Dermatology

摘　　要：目的比较中波高能紫外线和308nm准分子激光治疗白癜风的短期疗效。方法中波高能紫外线组患者40例，每周照射2次；308nm准分子激光组40例，每周1次。评估两组治疗8周后的皮损复色情况。结果经过8周的阶段治疗，中波高能紫外线组有83．6％皮损可出现不同程度的复色反应，达显效以上复色为42．1％；308nm准分子激光组86．1％有皮损不同程度色素生成，达到显效以上为50％。对于面部白癜风皮损中波高能紫外线的疗效低于308nm准分子激光（x2=4．32，P〈0．05），在其余部位两组有效率差异无统计学意义。在皮损起始复色的累积剂量方面，两者差异无统计学意义（t=0．89，P〉0．05），在达到显效以上复色方面，高能中波紫外线的治疗次数和累积剂量明显多于308nm准分子激光（P〈0．01）。两者均适用于儿童患者及活动期皮损。结论中波高能紫外线或308l＇lm准分子激光治疗白癜风均可在短期内起效且安全，308nm准分子激光疗效更明显。Objective To compare the short-term efficacy of high-intensity ultraviolet B （UVB） versus 308-nm excimer laser for the treatment of vitiligo. Methods Eighty patients with vitiligo were equally divided into two groups to be treated with high-intensity UVB twice a week or 308-nm excimer laser once a week for eight weeks. Repigmentation was evaluated at the end of the treatment. Results After eight weeks of treatment, repigmentation of different degrees was observed in 83.6% and 86.1%, and marked repigmentation in 42.1% and 50%, of the UVB- and excimer laser-treated lesions, respectively. The response rate was significantly lower in facial lesions receiving high-intensity UVB radiation than in those receiving excimer laser radiation （49.1% vs. 68.4%, X2 = 4.32, P 〈 0.05）, but similar at the other body sites between the two treatment （all P 〉 0.05）. The cumulative dosage required for initial repigmentation was similar between high-intensity UVB and 308-nm excimer laser （t = 0.89, P 〉 0.05）, while the treatment sessions and cumulative dosage required for marked or better repigmentation were significantly increased in UVB- compared with excimer laser-treated lesions （both P 〈 0.01）. In addition, both high-intensity UVB and 308-nm excimer laser were suitable for childhood and active vitiligo. Conclusions Both high-intensity UVB and 308-rim excimer laser are safe and effective in the treatment of vitiligo with rapid onset of action, and the latter appears to be superior to the former in efficacy.

关 键 词：白癜风 准分子激光 紫外线 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]