社会心理因素和5-羟色胺转运体基因多态性与哮喘易感性的关联分析  

Association analysis of social and psychological factors and 5-hydroxytryptamine transporter gene to asthma susceptibility

作　　者：许建国[1] 林健燕 马迎教[3] 廖建英 梁建成[3] 

机构地区：[1]右江民族医学院附属医院呼吸内科,百色533000 [2]南宁市疾病预防控制中心,南宁530011 [3]右江民族医学院公共卫生与管理学院,百色533000

出　　处：《上海交通大学学报（医学版）》2014年第1期48-52,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81060004);广西教育厅科研项目(201106LX456);广西卫生厅科研项目(Z2011144)~~

摘　　要：目的探讨社会心理因素与5-羟色胺转运体基因(5-HTT)多态性对广西汉族人群哮喘发病的影响。方法采用激惹、抑郁和焦虑自评量表(IDA)、特质应对方式问卷(TCSQ)、社会支持评定量表(SSRS)及一般情况调查表,对广西汉族175例哮喘患者和180名健康对照者的社会心理因素进行测评;采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测5-HTT基因Stin2和5-HTTLPR/rs25331位点的基因型及等位基因频率。结果多因素Logistic回归分析结果显示:较高的受教育程度和主观支持是哮喘发病的保护因素(OR=0.288,P=0.000;OR=0.898,P=0.000),内向性激惹是哮喘发病的危险因素(OR=1.205,P=0.011)。哮喘组与对照组的Stin2、5-HTTLPR/rs25331基因型和等位基因频率分布比较,差异均无统计学意义(P>0.05)。结论某些社会心理因素在哮喘的发病中起着重要作用,尚不能确定5-HTT基因多态性与哮喘的发病有关。Objective To investigate effects of the social and psychological factors and 5-hydroxytryptamine transporter （5-HTT） gene to asthma susceptibility in Han nationality in Guangxi Zhuang Autonomous Region. Methods IDA （ irritability, depression, and anxiety scale）, TCSQ （trait coping style questionnaire）, SSRS （social support rating scale）, and general situation investigation list were used to evaluate the social and psychological factors on 175 asthma patients and 180 healthy people as control group. Genotypes and alleles of Stin2 and 5-HTTLPR/rs25331 polymorphism were examined with polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） technique. Results Logistic regression analysis showed that high level of education and subjective support were protective factors for asthma （ OR = 0. 288, P =0. 000; OR =0. 898, P =0. 000）, while inward irritability was a risk factor （ OR = 1. 205, P =0. 011）. There was no significant difference between asthma and control group with the Stin2, 5-HTTLPR/rs25331 genotype, and allele frequencies （P 〉 O. 05）. Conclusion Some of the social and psychological factors play important roles in the pathogenesis of asthma, but it is still uncertain if 5-HTT gene polymorphism is relevant to the pathogenesis of asthma.

关 键 词：5-羟色胺转运体基因 社会心理因素 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]