PCI围手术期血小板聚集功能的临床检测及进展  

Research advance in platelet aggregation function test during PCI

作　　者：牟彦红 彭瑜[1] 张钲[1] 

机构地区：[1]兰州大学第一医院心血管内科兰州,730000

出　　处：《临床心血管病杂志》2014年第1期11-13,共3页Journal of Clinical Cardiology

摘　　要：经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)是冠心病血运重建的主要方式,术后标准的双联抗血小板治疗是预防支架内血栓形成等不良心血管事件的基础治疗。不同个体对抗血小板药物的反应性不同,对抗血小板药物低反应的患者发生血管事件的概率就增大。强化抗血小板治疗能减少术后血栓性事件的发生,但同时也增加了出血风险。床旁血小板聚集功能的检测可即时监测血小板反应性,使抗血小板药物在降低血栓性事件风险的同时又不额外增加出血风险,指导抗血小板药物在PCI术后患者中的个体化治疗。本文就PCI术后血小板聚集功能的临床检测方法及最新进展做一综述。Percutaneous coronary intervention（PCI）is the dominant procedure to execute revascularization in coronary heart disease（CHD）.Clopidogrel and aspirin play a central role in preventing stent thrombosis of patients undergoing PCI.Platelet function inhibition by aspirin or clopidogrel differs from individual.Analysis of platelet aggregation function can reflect the degree of platelet reactivity during treatment,which could reduce atherothrombotic events by decreasing bleeding complications,and also can guide the individualization therapy of antiplatelet in patient with PCI.This review focused on the lasted methods to monitor the function of platelet aggregation.

关 键 词：冠心病 血小板聚集 阿司匹林抵抗 氯吡格雷抵抗 

分 类 号：R541.4[医药卫生—心血管疾病]