STAT3:慢性炎症介导肿瘤发生和进展的关键节点  

STAT3:The Key Player in The Network of Inflammation and Cancer

作　　者：侯嘉杰[1] 孙倍成[1] 

机构地区：[1]南京医科大学第一附属医院肝脏移植中心,南京210029

出　　处：《生物化学与生物物理进展》2014年第1期69-78,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金委杰出青年基金资助项目(81225017)~~

摘　　要：炎症与肿瘤是近年来肿瘤领域的研究热点.在肿瘤发生、发展过程中,白介素6(interleukin-6,IL-6)等炎症因子可将肿瘤细胞与其所处的肿瘤微环境编织成一个炎性网络,而信号传导蛋白和转录激活物(signal transducers and activators of transcription 3,STAT3)正是这一炎性网络中的关键节点,在慢性炎症介导肿瘤形成的过程中发挥重要作用.本文从STAT3的信号通路构成入手,由肿瘤细胞及肿瘤微环境两方面展开,综述了肿瘤发生发展过程中STAT3在肿瘤细胞及各种炎症/免疫细胞中的作用,以及靶向STAT3治疗肿瘤的转化医学研究进展.Within several decades, the area of inflammation and cancer has attracted great attention. During the process of tumor initiation and progression, a variety of inflammatory cytokines including interleukin-6 entangle tumor cells and the surrounding tumor microenvironment into an inflammatory net; STAT3 （signal transducers and activators of transcription 3） is the key player in the net that persistently promotes tumor development. This review begins with the composition of STAT3 signaling pathways, and discusses its role in different cell types regarding the network between tumor cells and tumor microenvironment, and its advance in translational research on targeted cancer therapy.

关 键 词：炎症 肿瘤 STAT3 

分 类 号：R392[医药卫生—免疫学]