HBeAg对护理操作中乙型肝炎病毒传染源的预警效果  

Predictive Effects of HBeAg to HBV Infective Source in Nursing Procedures

作　　者：李健[1] 姜旻岚[2] 刘瑜[2] 缪镇 杨双旺[2] 李宗香[3] 

机构地区：[1]解放军第454医院护理部,江苏南京210002 [2]解放军第454医院感染控制科 [3]南京军区福州总医院第476临床部医院感染控制科,福建福州350002

出　　处：《解放军护理杂志》2013年第23期48-50,共3页Nursing Journal of Chinese People's Liberation Army

摘　　要：目的探讨HBeAg对护理操作中乙型肝炎病毒（hepatitis Bvirus，HBV）传染源的预警效果。方法采集2010年2—8月解放军第454医院连续收治入院的992例手术患者的空腹静脉血各3ml，分离血清于-40℃保存备用；从992份血清样本中分别检出HBsAg和HBeAg阳性样本并进行定量检测，比较HBV感染量在HBeAg阳性和阴性的HBsAg阳性者之间的差异。结果992例手术患者中检出HBsAg阳性156例，其中HBeAg阳性31例、阴性125例。HBeAg阳性和阴性的HBsAg阳性者的HBVDNA阳性率分别为100．0％和67．20．4；传染性范围分别在1×10^2～1×10^9ID／ml和（0～1）×10^6ID／ml。6．4％HBeAg阳性和92．8％阴性的HBsAg阳性者的HBV感染量〈1×10^4ID／ml；93．6％HBeAg阳性和7．2％阴性的HBsAg阳性者HBV感染量≥1×10^4ID／ml；19．3％HBeAg阳性HBsAg阳性者HBV感染量≥1×10^7.5ID／ml。结论在护理人员进行有效乙肝疫苗免疫的基础上，以HBeAg为指标对护理操作中HBV传染源的预警效果较HBsAg更好，使用HBeAg监控法预防护理人员职业感染的效果比HBsAg监控法更好。Objective To investigate the predictive effects of HBeAg to HBV infective source in nursing procedures. Methods HBsAg and HBeAg were detected in 992 consecutive surgical patients admitted to the operation. For HBeAg positive and negative HBsAg carriers,the infectious quantitative detection and classification were conducted. Results Among 992 surgical patients, 156 cases were detected as HBsAg positive. In the 156 cases,31cases were HBeAg positive,and the others were negative. HBV DNA positive ratio of HBeAg positive and negative HBsAg carriers are 100.0% and 67.2% respectively,and their infectivity ranged between 1×10^2-- 1 ×10^9 ID/ml and 0--1 ×10^6 ID/ml. Approximately 6.4 % HBeAg positive and 92.8% negative HBsAg carriers, HBV concentration was 〈1×10^4 ID/ml;About 93.6% HBeAg positive and 7.2 ; negative HBsAg carriers, HBV concentration was ; 1×10^4 ID/ml; About 19.3 ; HBeAg positive HBsAg carriers, HBV concentration was ≥1 ×10^7.5 ID/ml. Conclusion On basis of inoculating HBV vaccine among nursing staff,the predictive effect HBsAg. The potency ratio by using HBeAg controlling of HBeAg to HBV infective source was better than measures to prevent occupational HBV infection of nurses was higher than HBsAg. Its maneuverability,or practicability,needs more investigation.

关 键 词：乙型肝炎表面抗原 乙型肝炎病毒 乙型肝炎E抗原 医院感染 

分 类 号：R512.62[医药卫生—内科学]