人体特异性免疫力对日本血吸虫再感染的影响研究  

The Effect of Human-specific Immunity against Schistosoma japonicum on Infection Rate of Schistosomiasis

作　　者：杨慧 张剑平 戴文新 赵义娟 彭佩生 

机构地区：[1]大理州血吸虫病防治研究所,云南大理671000

出　　处：《大理学院学报（综合版）》2013年第12期59-60,共2页Journal of Dali University

摘　　要：目的：研究人群特异性免疫力对日本血吸虫感染率的影响。方法：选择粪检血吸虫阳性91人（A组）和粪检血吸虫阴性223人（B组）作为研究对象。两组人群经吡喹酮治疗后10d，将观察对象同时暴露在水稻栽插期，栽插期结束后30d用粪检查病，观察两组感染率是否有差异，以此推断特异性免疫力对人群血吸虫感染率的影响。结果：A组感染率（再感染率）为38．46％（35／91），其中6—14岁儿童感染率（再感染率）为10．53％（2／19），15～60岁人群感染率（再感染率）为45．83％（33／72）。B组的感染率为29．60％（66／223），其中6～14岁儿童感染率为20．27％（15／74），15～60岁人群感染率为34．23％（51／149）。结论：人体感染日本血吸虫后产生的特异性免疫力较弱，对降低人群再感染无明显作用。Objective： To research the effect of specific immunity against Schistosomajaponicum on infection rate of schistosomiasis in human. Methods： 91 （A group） with positive stool examination of S. japonicum and 223 negative individual （B group） have been selected as research object. After treatment with praziquantel for 10 days, the two groups simultaneously were exposed in rich planting period. Moreover, after planting period for 30 days, fecal examination was also used to observe infection rate whether there were different, in order to infer specific immunity against schistosome infection influence. Results： The infection rate of group A （reinfection） was 38.46% （35/91）, in which children aged 6-14 with the infection rate （re-infection） of 10.53% （2/19）; the infection rate of 15-60 year olds （re-infection rate） was 45.83% （33/72）. The infection rate of group B （re-infection） was 29.60% （66/223）, in which children aged 6-14 with the infection rate （re-infection） of 20.27% （15/74）; the infection rate of 15-60 year olds （re- infection rate） was 34.23% （51/149）. Conclusion： The specific immunity is relatively low and week resulted from S. japonicum infection, and it had no significant effect in reducing infection rate.

关 键 词：日本血吸虫 特异性免疫力 感染率 

分 类 号：R383.24[医药卫生—医学寄生虫学]