氟比洛芬酯不同给药时机对妇科腹腔镜术后镇痛效果的影响  

Flurbiprofen axetil administrated at different time points in preemptive analgesia after gynecologic laparoscopic surgery:a comparison of analgesic effects

作　　者：安小虎[1] 徐韬[1] 余大松[1] 

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院麻醉科,上海200030

出　　处：《上海医学》2013年第12期1006-1008,共3页Shanghai Medical Journal

摘　　要：目的观察氟比洛芬酯不同给药时机对妇科腹腔镜术后镇痛效果的影响。方法择期行妇科腹腔镜手术的患者120例(每组40例),被随机均分入3组:麻醉前给药组患者麻醉诱导前静脉注射氟比洛芬酯100mg,手术结束给药组患者手术结束后静脉注射氟比洛芬酯100mg,空白对照组不应用氟比洛芬酯。术后采用疼痛视觉模拟评分法(VAS评分)对拔除气管插管后即刻(T0)和术后1(T1)、4(T2)、8(T3)、12(T4)、24h(T5)的切口痛和内脏痛(主诉有便意)进行评分;患者不能忍受疼痛时给予镇痛药治疗,记录术后24h内镇痛药使用的例数和使用次数。结果麻醉前给药组、手术结束给药组在T0至T4时间点的切口痛、内脏痛VAS评分均显著低于空白对照组(P值均<0.05),前两组间术后同时间点的切口痛和内脏痛VAS评分的差异均无统计学意义(P值均>0.05)。麻醉前给药组、手术结束给药组和空白对照组患者在术后24h内需要镇痛药物治疗的例数/次数分别为2/2、2/3、9/11,空白对照组显著多于麻醉前给药组、手术结束给药组(P值均<0.05)。结论氟比洛芬酯超前镇痛用于妇科腹腔镜手术,术后镇痛效果显著,但术前与术后给药的镇痛效果相似。Objective To observe the analgetic effects of flurbiprofen axetil at different time points on preemptive analgesia in gynecologic laparoscopic surgery. Methods A total of 120 patients scheduled for gynecological laparoscopic operation were randomly divided into three groups （n = 40）. Flurbiprofen axetil （ 100 mg） was injected intravenously before induction of anesthesia in group A and at the end of the surgery in group B. No flurbiprofen axetil was used in group C. Visual analogue scale （VAS） was used to evaluate incision pain and visceral pain after extubation （To）, and 1 （T1） ,4（T2 ） ,8 （T3）, 12 （T4） and 24 h（T5 ） postoperatively. The amount and frequency of postoperative analgesic were recorded. Results The VAS scores of group A and group B were significantly lower than those in group O at To, T1, T2, T3 and T4 （all P 〈 0. 05）. There was no significant difference in the VAS score of incision pain or visceral pain between group A and group B （all P^0.05）. The amount and frequency of the need for postoperative analgesic in group O （9/11 ） were significantly more than those in group A （2/2） and group B （2/3） （both P〈0.05）. Conclusion Preemptive analgesia of flurbiprofen axetil is effective for gynecological laparoscopic surgery. However, there is no significant difference in analgetic effects between preoperative and postoperative application of flurbiprofen axetil.

关 键 词：氟比洛芬酯 超前镇痛 妇科腹腔镜手术 

分 类 号：R614[医药卫生—麻醉学]