龙抗Ⅰ号对模拟微重力大鼠血液流变学的影响及心肌氧化损伤的保护研究  

Effect of Drageny I on Blood Rheology and Oxidative Damage of Myocardium in Rats Under Simulated Microgravity

作　　者：李玉娟[1] 陈博[1] 甘琳[1] 高铁[1] 乔瑾渊 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081

出　　处：《北京理工大学学报》2013年第12期1313-1316,共4页Transactions of Beijing Institute of Technology

基　　金：国家自然科学基金资助项目(81202996)

摘　　要：观察传统名贵中药龙抗I号对尾吊模拟微重力大鼠血液流变学的影响及心肌氧化损伤的保护作用.SD大鼠分为对照组、模型组、给药组,分别在5,21d取静脉血检测红细胞压积、红细胞变形和全血黏度,取血后取心肌测定过氧化氢(H2O2)、丙二醛(MDA)和总超氧化物歧化酶(T-SOD)水平.给药5d后,给药组与模型组比较,红细胞压积、心肌MDA水平明显降低;全血黏度、心肌H2O2质量分数有降低趋势;红细胞最大变形指数、心肌T-SOD活力有升高趋势.21d后,给药组与模型组比较,全血黏度显著下降,红细胞最大变形指数显著升高;其余指标均表现出向正常水平恢复的趋势.龙抗I号对尾悬吊模拟微重力引起的大鼠红细胞压积升高、全血黏度增大、红细胞变形能力下降有明显的抑制并且对模拟微重力引起的心肌氧化损伤有一定的保护作用.It is the first time to investigate effects, on the blood rheology and the protection on oxidative damage in myocardium in tail-suspended rats of Drageny I, which is a kind of rare TCM herbs. SD rats are randomly divided into three groups： control group, model group and drug group. The blood rheology and the oxidative damage （the level of H202, MDA and T-SOD） of myocardium are examined in ways as follows：veinal blood and myocardium test after 5 d and 21 d tail-suspension respectively. Compared with the model group, the hematocrit and the level of myoeardium MDA in drug group decrease significantly after 5 d of tail-suspension. Red blood cell maximum deformation index, whole blood viscosity, the level of HzO2 and T-SOD of myoeardium show no significant changes. After 21 d of tail-suspension, whole blood viscosity of the drug group decreases significantly while red blood cell maximum deformation index increases remarkably. Other indexes show recovery tendency. Drageny I significantly inhibits the increase in hematoerit and blood viscosity while increasing the red blood cell maximum deformation index in tail-suspended rats. It also shows protective effects on the myocardium from oxidative stress in rats under the simulated microgravity condition.

关 键 词：模拟微重力 龙抗Ⅰ号 血液流变学 氧化应激 

分 类 号：R859[医药卫生—航空、航天与航海医学]