右归饮防治类风湿性关节炎大鼠膝关节骨吸收的研究  

Effect of Youguiyin on Bone Resorption of Knee Joint of Rheumatoid Arthritis Rats

作　　者：田东林[1] 高国卫[1] 黄杰烽[2] 陈俊杰[2] 王翀邦 杜文喜[4] 

机构地区：[1]浙江中医药大学第一临床医学院 [2]浙江省中医院 [3]大连65711部队医院 [4]浙江中医药大学

出　　处：《山西中医学院学报》2013年第5期11-13,共3页Journal of Shanxi College of Traditional Chinese Medicine

基　　金：浙江省自然科学基金(Y2111092);国家自然科学基金(81202709)

摘　　要：目的:观察右归饮抗类风湿性关节炎(RA)大鼠膝关节骨吸收的疗效。方法:SD大鼠60只随机分为空白对照组、模型组、右归饮组、甲氨蝶呤组。8 w后处死大鼠,获取膝关节标本,检测膝关节骨密度值,拍摄其钼靶片,并行病理检测。结果:与模型组比较,右归饮组、甲氨蝶呤组大鼠膝关节骨密度升高,差异有统计学意义(P<0.05);钼靶片示以上二组骨小梁较致密;镜检示右归饮、甲氨蝶呤均能抑制膝关节软骨破坏及炎症细胞浸润。上述作用右归饮优于甲氨蝶呤。结论:右归饮通过抑制RA大鼠膝关节软骨破坏,抑制炎细胞浸润而发挥抗RA大鼠膝关节骨吸收的作用。Objective：To observe the effect of Youguiyin on bone resorption of knee joint of rats with rheumatoid arthritis. Methods：60 rats were randomly divided into blank control group, model group, Youguiyin group and methotrexate group. 8 w later,rats were sacrificed and samples of knee joint were obtained. Bone density detection and pathological examination of knee joint were underwent, and x-ray of molybdenum target of knee joint was shot. Result：Compared with model group, bone mineral density of knee joint was increased in Youguiyin group and methotrexate group （P〈0.05）. X-ray of molybde- num target indicated ：bone trabecula in Youguiyin group and methotrexate group was more compacter than that in model group. Microscopic examination indicated that Youguiyin and methotrexate could inhibit cartilage destroy and inflammatory cell infiltration of knee joint. Effects of Youguiyin were better than those of methotrexate. Conclusion ： Youguiyin could re- strain bone resorption through inhibiting cartilage destroy and inflammatory cell infiltration of knee joint of RA rats.

关 键 词：右归饮 类风湿性关节炎 大鼠 

分 类 号：R285.5[医药卫生—中药学]