坤泰胶囊对子宫切除术后妇女卵巢功能及围绝经期症状的影响  

Effects of Kuntai capsule on ovarian function and perimenopause symptoms of women with hysterectomy

作　　者：王红英[1] 支聪聪[1] 赵春兰[1] 姚克文[1] 王建[1] 黄瑛[1] 李友良[2] 刘淑敏[1] 

机构地区：[1]保定市妇幼保健院,河北保定071000 [2]保定市卫生局,河北保定071000

出　　处：《医学研究与教育》2013年第6期22-25,共4页Medical Research and Education

基　　金：保定市科学技术研究与发展计划项目(11ZFO35)

摘　　要：目的探讨坤泰胶囊对子宫切除术后妇女卵巢功能及围绝经期症状的影响。方法收集来院就诊142例良性病变切除子宫后应用坤泰胶囊治疗的病例资料,与应用雌激素治疗者做比较。结果 2组间E2、FSH、LH水平比较差异有统计学意义(F E2=8.217,P E2=0.000;F FSH=6.727,P FSH=0.000;F LH=5.964,P LH=0.000),其中FSH、LH水平坤泰组均高于激素组;E2水平在治疗3个月后比较差异有统计学意义(t=3.149,P=0.004),坤泰组高于激素组;治疗6个月后水平差异无统计学意义(t=0.892,P=0.611)。不同时间E2、FSH、LH分析表明差异有统计学意义(F E2=7.538,P E2=0.000;F FSH=4.558,P FSH=0.007;F LH=12.148,P LH=0.000),两两比较显示治疗后E2水平升高,FSH、LH水平下降。2组间卵巢体积差异无统计学意义(F=0.018,P=0.895);不同时间卵巢体积差异亦无统计学意义(F=0.112,P=0.798)。2组均未见明显的卵巢血流及窦卵泡变化;2组在改善围绝经期症状总有效率方面差异无统计学意义,坤泰组较激素组乳房胀痛发生例数少,但差异无统计学意义(P>0.05)。结论坤泰胶囊在治疗子宫切除术后患者围绝经期综合征方面有效,为围绝经期综合症患者增加了一种新的选择。Objective To study the effects of Kuntai Capsule on ovarian function perimenopausal symptoms of women with hysterectomy. Methods 142 cases who suffered from benign diseases with hysterectomy were randomly divided into two groups： Kuntai capsule group and estrogen group. Results There were significant difference between the 2 groups about the levels of E2, FSH and LH （FE2=8.217, PE2=0.000. FFSH=6.727, PFSH=0.000. FLH=5.964, PLH=0.000）. While the levels of FSH, LH in Kuntai capsule group were higher than those in estrogen group, the difference were significant. The level of E2 in Kuntai capsule group was higher than that of the estrogen group after 3 months therapy （t=- 3.149, P=0.004）, while there was no significant difference after 6 months therapy （t=0.892, P=0.611）. The levels of E2, FSH and LH were different between the 2 groups in different therapy times （FE2=7.538, PE2=0.000. FFsu =4.558, PFSH =0.007. FLH=12.148, PLH=0.000）. The level of E2 was increased but FSH and LH were decreased. There was no significant difference of ovarian volume between the 2 groups （F=0.0 18, P=-0.895）, and thedifference of ovarian volume in different therapy times was not significant （F=0.112, P=0.798）. The total effective rate of improving perimenopausal symptoms had no significant difference between the 2 groups. The incidence rate of breast distending pain and colporrbagia of Kuntai capsule group were lower than that of estrogen group but the difference was not significant. Conclusion Kuntai Capsule has obvious effects on the treatment of patients with hysterectomy, and it gives a new choice in treating patients with perimenopausal symptoms.

关 键 词：子宫切除 坤泰胶囊 围绝经期症状 卵巢功能 

分 类 号：R711[医药卫生—妇产科学]