H型高血压、LDL对冠心病患者冠脉病变程度的影响  

Influence of H-hypertension and LDL on severity of coronary artery in patients with coronary heart disease

作　　者：林荣汉[1] 何宗云[2] 黎运西[3] 

机构地区：[1]南方医科大学附属顺德第一人民医院门诊内科,佛山528300 [2]南方医科大学附属顺德第一人民医院心血管内科,佛山528300 [3]南方医科大学附属顺德第一人民医院检验科,佛山528300

出　　处：《国际医药卫生导报》2014年第2期183-187,共5页International Medicine and Health Guidance News

摘　　要：目的 探讨H型高血压、LDL对冠心病患者冠脉病变程度的影响.方法 选取我院2009年6月至2011年12月收治的158例冠心病患者为研究对象,根据有没有高血压分为高血压冠心病组和正常血压冠心病组,再按照血清同型半胱氨酸（Hcv）水平的不同,将高血压冠心病组分为H型高血压冠心病组（Hcy≥10μmol/L）和单纯性高血压冠心病组（Hcy＜10 μmol/L）,根据冠状动脉造影结果分为单支病变、双支病变、多支病变三组,将冠状动脉造影正常者20例作为对照组,比较高血压冠心病组、正常血压冠心病组、H型高血压冠心病组和单纯性高血压冠心病组患者的Hcy、低密度脂蛋白（LDL）、冠状动脉狭窄程度及病变支数等指标,观察H型高血压对冠心病患者冠脉病变程度的影响.结果 H型高血压组血清Hcy、LDL水平、冠心病患者冠状动脉狭窄程度、病变支数明显高于单纯性高血压组、正常血压冠心病组和对照组（P＜0.01）,具有统计学意义,而且狭窄程度越明显,病变支数越多,其血清Hcy、LDL水平越高.结论 H型高血压血清Hcy、LDL水平与冠心病患者冠状动脉狭窄程度及病变支数密切相关,监测血清Hcy、LDL水平变化对于冠心病及H型高血压患者早期诊断治疗具有非常重要意义.Objective To explore the influence of H-hypertension and LDL on the severity of coronary artery in patients with coronary heart disease. Methods 158 patients with coronary heart disease admitted and treated in our hospital from June 2009 to December 2011 were selected. These patients were divided into a coronary artery disease with H-hypertension group and a coronary artery disease with normal blood pressure group according to whether the patients had hypertension. Then the former was divided into an H-hypertension group（Hcy /〉 10 tx mol/L）and a simple hypertension group （Hcy〈10 Ix mol/L） according to different levels of homocysteine （Hcy）. Meanwhile, they were divided into a single branch abnormal coronary group, a two branches abnormal coronary group, and a three branches abnormal coronary group according to the angiography results. 20 cases with normal angiography were taken as a control group. The levels of serum homocysteine and LDL, the severvity of coronary stenosis etc. in these groups were compared. The influenceof H-hypertension and LDL on the severity of coronary artery in patients with coronary heart disease was observed. Results The levels of serum homocysteine and LDL were higher, stenosis degree of coronary artery was more severe, and more coronary branches occurred stenosis in the H-hypertension group than in the simple hypertension group, normal blood pressure group, and control group, with statistical differences（P〈0.01）. The levels of serum homocysteine and LDL increased with the severity of coronary artery and stenosis branch number. Conclusions The levels of serum homocysteine and LDL correlate with the severity of coronary artery and the stenosis branch number in the patients with coronary heart disease. The detection of the levels of serum homocysteine and LDL has high clinical value in the early diagnosis and treatment of coronary heart disease and H-hypertension.

关 键 词：H型高血压 冠心病 冠状动脉造影 低密度脂蛋白 同型半胱氨酸 

分 类 号：R541.4[医药卫生—心血管疾病]