硝苯地平控释片与氢氯噻嗪治疗老年高血压的研究  

Controlled release tablets of nifedipine and hydrochlorothiazide for senile hypertension

作　　者：林宇彪[1] 林康华[1] 宁观林[1] 

机构地区：[1]吴川市人民医院,525400

出　　处：《国际医药卫生导报》2014年第2期190-192,共3页International Medicine and Health Guidance News

摘　　要：目的 探讨盐酸贝那普利联合硝苯地平控释片或氢氯噻嗪治疗老年高血压的临床疗效比较.方法 选取140例3级老年高血压患者,随机分为观察组（70例）和对照组（70例）,观察组给予贝那普利10 mg,早上1次,硝苯地平控释片30 mg,早上1次;对照组贝那普利10 mg,早上1次,氢氯噻嗪25 mg,早上1次,观察入选时和治疗4周后,收缩压和舒张压的变化.结果 治疗前,观察组平均血压为：（187.3±5.2）/（115.5±2.4） mmHg,对照组平均血压为：（186.2±5.5）/（116.2±2.2） mmHg,差异均无统计学意义（P＞0.05）;治疗后,观察组平均血压为：（135.1±1.5）/（83.3±2.2） mmHg,对照组平均血压为：（142.2±2.1）/（89.1±2.5）mmHg,差异有统计学意义（P＜0.05）;观察组的总有效率为90％,对照组的总有效率为80％,差异有统计学意义（P＜0.05）.结论 观察组和对照组均能降低3级老年高血压,观察组疗效优于对照组,具有起效快、作用强、易于达标特点.Objective To investigate the clinical efficacies of Benner Pury hydrochloride combined with nifedipine tablets or hydrochlorothiazide in the treatment of hypertension in the elderly. Methods 140 patients with grade 3 hypertension were randomly divided into an observation group （70 cases） and a control group （70 cases）. The observation group was given Benner Pury 10 mg one time and controlled release tablets of nifedipine 30 mg one time in the morning; the control group was given Benner Pury 10 nag one time and hydrochlorothiazide 25 tug one time in the morning. The changes of systolic and diastolic blood pressures were observed at the beginning of the selection and after 4 weeks＇ treatment. Results Before the treatment, the average blood pressure was （187.3 ± 5.2） / （115.5 ±2.4） mmHg in the observation group and was （186.2± 5.5） / （116.2 ± 2.2） mmHg in the control group, with no statistical difference （P 〉 0.05）. After the treatment, the average blood pressure was （135.1 ±1.5） / （83.3± 2.2） mmHg in the observation group and was （ 142.2 ± 2.1 ） / （ 89.1 ± 2.5 ） mmHg in the control group. The total effective rate was 90% in the observation group and was 80% in the control group, with a statistical difference （P〈0.05）. Conclusions Grade 3 elderly hypertension decreased in both the observation group and the control group. The curative effect was better in the observation group than in the control group. The treatment method of the observation group had a rapid onset and strong action and was easy to meet the standard.

关 键 词：硝苯地平控释片 氢氯噻嗪 老年高血压 降压 

分 类 号：R544.1[医药卫生—心血管疾病]