雌二醇判断早期先兆流产预后的价值  

Value of Estradiol in Judging Prognosis of Early Threatened Abortion

作　　者：生淑亭[1,2] 方芳[1,2] 

机构地区：[1]广西中医药大学第三附属医院 [2]柳州市中医院妇科,柳州市545001

出　　处：《广西医学》2014年第1期23-24,共2页Guangxi Medical Journal

基　　金：广西中医药管理局资助项目(GZPT13-15)

摘　　要：目的探讨血清雌二醇水平对判断早期先兆流产预后的价值。方法根据妊娠结局将102例早期先兆流产患者分为持续妊娠组83例和妊娠失败组19例。采用化学发光免疫法测定两组治疗前血清雌二醇水平。结果持续妊娠组血清雌二醇水平为(1279.23±352.33)pg/ml,明显高于妊娠失败组的(399.47±152.63)pg/ml(P<0.05);持续妊娠组血清雌二醇≥991 pg/ml比例为65.06%(54/83),明显高于妊娠失败组的10.53%(2/19)(P<0.05);ROC曲线下面积为0.716,标准误为0.075,血清雌二醇水平预测先兆流产患者妊娠预后有统计学意义(P<0.05);以雌二醇水平为991 pg/ml判断妊娠预后的灵敏度为62.7%,特异度为21.7%。结论血清雌二醇对判断先兆流产预后的具有一定价值。Objective To investigate the value of serum estradiol in judging the prognosis of early threatened abortion . Methods One hundred and two patients suffering early threatened abortion were divided into two groups according to pregnancy outcomes ,83 patients in continued pregnancy group and 19 patients in pregnancy failure group .Serum estradiol level was detected in both groups before treatment chemiluminescence immunoassay .Results Serum estradiol level of continued pregnancy group was （1 279.23 ±352.33）pg/ml,which was significantly higher than that of pregnancy failure group[（399.47 ±152.63）pg/ml,P〈0.05].The proportion of patients whose serum estradiol≥991 pg/ml in the continued pregnancy group（65.06%,54/83） was significantly higher than that in the pregnancy failure group （10.53%,2/19）（P〈0.05）. ROC area under the curve was 0.716 and standard deviation was 0.075,serum estradiol level applied to predicting the prognosis of patients with threatened abortion was statistically significant （ P〈0 .05 ）;With a standard of estradiol level （991 pg/ml） for judging pregnancy outcomes ,the sensitivity was 62.7%and the specificity was 21.7%.Conclusion Serum estradiol level has some value in judging the prognosis of threatened abortion .

关 键 词：先兆流产 雌二醇 预后 妊娠 

分 类 号：R714.21[医药卫生—妇产科学]