脉冲振荡法测定在COPD患者中的应用研究  

Clinical application of impulse oscillation in chronic obstructive pulmonary disease

作　　者：章敬玉[1] 罗勇[1] 沈礼娟[1] 邓桂胜[1] 吴刚[1] 

机构地区：[1]上海交通大学附属新华医院崇明分院,上海202150

出　　处：《临床肺科杂志》2014年第2期208-211,共4页Journal of Clinical Pulmonary Medicine

基　　金：上海市崇明县科学技术发展基金项目(No.CKY2012-17)

摘　　要：目的探讨脉冲振荡法(IOS)测定在慢性阻塞性肺疾病(COPD)患者中的临床应用。方法选择100例COPD患者(COPD组)和50例健康体检者(对照组),比较二者常规肺功能检测及IOS检测结果,并分析两种方法的相关性。结果与对照组比较,COPD组用力肺活量(FVC),第1s用力呼气容积(FEV1)、第1 s用力呼气容积/用力肺活量百分比(FEV1/FVC%)、FEV1实测值/预计值(FEV1/Pre%)均显著降低(P<0.05);COPD组共振频率(Fres)、呼吸总阻抗(Zrs)、5 Hz时呼吸总阻抗(Z5)、5 Hz时电抗(X5)、总气道阻力(R5)、中心气道阻力(R20)、周边气道阻力(R5-R20)、中心阻力(Rc)及周边阻力(Rp)均较对照组显著升高(P<0.05);Fres、R5、R20、R5-R20与FEV1、FEV1/FVC%、FEV1/Pre%均呈显著负相关(P<0.05)。结论 IOS测定可较好地反映COPD患者气道阻力的变化,联合常规肺功能测定可更好地判断COPD患者的气道堵塞及病情变化,尤其适用于老年患者。Objective To explore the clinical application of impulse oscillation （lOS） in patients with chro- nic obstructive pulmonary disease （COPD）. Methods This study selected 100 COPD patients as the study group and 50 healthy people as the control group. They were all given respiratory function test and IOS test. Results There was a significant decrease in FVC, FEV~, FEVI/FVC%, and FEVl/pre% in the study group while compared with the control group （P 〈 0. 05）. The improvement of Fres, Zrs, ZS, XS, RS, R20, R5 - R20, Rc and Rp was more pronounced in the study group than in the control group （P 〈 0. 05）. Fres, RS, R20, R5 - Pt20 were negative- ly correlated with FEV1 , FEV1/FVC% , FEV~/Pre% （P 〈 0. 05）. Conclusion IOS can quickly reflect the airway resistance of COPD, and it can better identify airway blockage and their changes of illness combined with respiratory function tests, especially in elderly COPD patients.

关 键 词：慢性阻塞性肺疾病 脉冲振荡法 肺功能检测 

分 类 号：R563.9[医药卫生—呼吸系统]